Document Detail


Positron emission tomography in the initial staging of esophageal cancer.
MedLine Citation:
PMID:  12215149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the value of positron emission tomography (PET) compared with computed tomography (CT) in the initial staging of esophageal cancer. DESIGN: Case series. SETTING: Tertiary care veterans hospital. PATIENTS: Patients with newly diagnosed esophageal cancers from January 1996 through May 2001 who underwent both CT and PET scanning within 4 weeks were included in the study (n = 24). Only patients who underwent pathological or radiographic follow-up were included. MAIN OUTCOME MEASURES: The sensitivity, specificity, and negative and positive predictive values of CT and PET were determined based on a criterion standard of pathological staging in 16 patients (67%) and follow-up imaging in 8 patients (33%). RESULTS: For staging regional lymph node involvement, CT and PET scans showed no statistically significant difference in sensitivity (57% and 71%, respectively) and specificity (71% and 86%, respectively). For detection of metastatic disease, CT and PET showed no significant difference in sensitivity (83% and 67%, respectively) and specificity (75% and 92%, respectively). There was no significant difference in clinical decision making when the results of both tests were discordant. CONCLUSIONS: There was no significant difference between the 2 imaging modalities in the initial staging of esophageal cancer. The CT scan was a sensitive indicator of distant metastases, whereas PET was more specific. It is unclear what additional role PET scanning should have in the initial screening of patients.
Authors:
Sherry M Wren; Pascal Stijns; Sandy Srinivas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  137     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-06     Completed Date:  2002-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1001-6; discussion 1006-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Palo Alto Veterans Hospital, 3801 Miranda Ave, Palo Alto, CA 94304, USA. swren@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Esophageal Neoplasms / pathology,  radiography,  radionuclide imaging*
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Neoplasm Staging
Retrospective Studies
Sensitivity and Specificity
Tomography, Emission-Computed*
Tomography, X-Ray Computed

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