| Positron emission tomography in evaluating the feasibility of curative intent in cervical cancer patients with limited distant lymph node metastases. | |
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MedLine Citation:
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PMID: 18499238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Clinical outcomes of cervical cancer patients with distant lymph node (LN) metastases are poor. [(18)F] fluorodeoxyglucose positron emission tomography (PET) or PET/computed tomography (CT) scans could potentially benefit treatment plan. METHODS: Patients with cervical cancer whose CT/magnetic resonance imaging (MRI)-based imaging showed limited metastases to para-aortic lymph node (PALN), inguinal (ILN), and/or supraclavicular (SLN) were prospectively enrolled to evaluate whether PET or PET/CT influenced management. The clinical impact of PET or PET/CT was determined on a patient basis. RESULTS: Between November 2001 and April 2007, 47 patients were enrolled for suspected metastasis to PALN with (n=8) or without other distant nodal involvement (n=31), ILN (n=6), or SLN metastasis (n=2). Additional PET or PET/CT had positive clinical impact in 21 (44.7%) of the 47 study patients, 23 had no impact, and three had negative impact. Positive impact included disclosing additional curable sites (n=8), down-staging (n=6), offering metabolic biopsy (n=4) or change to palliation (n=3). The 2-year overall survival (OS) of the study patients was 56.9% with median follow-up time of 47.0 months (range: 8-71 months) in surviving patients. The 2-year OS rates for PALN (based on histology or CT/MRI-PET consensus) and histology-proven SLN metastasis were 50.6% and 24.7%, respectively. Two (40.0%) of the five patients with histology-proven ILN metastases had no evidence of disease. CONCLUSIONS: PET or PET/CT added benefit to primary treatment planning in cervical cancer with MRI-defined suspected distant nodal metastasis. |
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Authors:
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Angel Chao; Kung-Chu Ho; Chun-Chieh Wang; Hui-Hsin Cheng; Gigin Lin; Tzu-Chen Yen; Chyong-Huey Lai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-22 |
Journal Detail:
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Title: Gynecologic oncology Volume: 110 ISSN: 1095-6859 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-22 Completed Date: 2008-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 172-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / pathology, radionuclide imaging*, therapy* Feasibility Studies Female Fluorodeoxyglucose F18 / diagnostic use Humans Lymph Nodes / radionuclide imaging Lymphatic Metastasis Magnetic Resonance Imaging Middle Aged Positron-Emission Tomography Prospective Studies Tomography, X-Ray Computed Uterine Cervical Neoplasms / pathology, radionuclide imaging*, therapy* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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