Document Detail

Positron emission tomography in cardiovascular disease.
MedLine Citation:
PMID:  9191475     Owner:  NLM     Status:  MEDLINE    
Positron emission tomography (PET) represents an advanced form of nuclear imaging technology. The use of positron emitting isotopes, such as C-11, O-15, N-13, and F-18 permit radiolabelling of naturally occurring compounds in the body or close analogues. This, combined with technical advantages of PET imaging, allow quantification of physiological processes in humans. PET has become established as the most accurate noninvasive means for the diagnosis of coronary artery disease using myocardial perfusion radiotracers, which include rubidium-82, N-13-amonia, and O-15-water. These approaches have also been applied for long term evaluation of the effects of therapy and for the quantification of myocardial bloodflow. Radiolabelling of metabolic substrates, including C-11 palmitate, C-11 acetate and F-18 flurodeoxyglucose (FDG) have permitted evaluation of myocardial metabolism. F-18 FDG PET imaging has been established as the best means for defining viable myocardium in patients with reduced ventricular function being considered for revascularization. FDG PET can also identify patients being considered for cardiac transplant, who may be candidates for revascularization. In this review, other applications for metabolic, autonomic nervous system and receptor imaging are also discussed. The availability of cardiac PET in Canada is currently limited. However, with the reducing costs of capital and more cost effectiveness data, PET may become more widely available. Cardiac PET imaging is established as a tremendous diagnostic tool for defining viable myocardium, assessment of perfusion and long term evaluation of therapy without invasive procedures. PET is also a vital research tool capable of evaluating flow, metabolism, myocardial receptors, autonomic nervous system and potentially radiolabelled drugs. Cardiac PET imaging will continue to provide important insight, expanding our understanding and treatment of patients with cardiovascular disease.
R Beanlands
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  12     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-07-07     Completed Date:  1997-07-07     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  875-83     Citation Subset:  IM    
Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario.
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MeSH Terms
Coronary Circulation / physiology
Coronary Disease / radionuclide imaging
Deoxyglucose / analogs & derivatives,  diagnostic use
Fluorine Radioisotopes / diagnostic use
Fluorodeoxyglucose F18
Heart Diseases / radionuclide imaging*
Heart Transplantation
Myocardium / metabolism
Tissue Survival
Tomography, Emission-Computed*
Reg. No./Substance:
0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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