| Positron emission tomography/computed tomography: diagnostic accuracy in lymphoma. | |
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MedLine Citation:
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PMID: 17032175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An accurate initial staging of patients with non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) is critical for the selection of an appropriate treatment. Computed tomography (CT) remains the standard imaging technique, although it is based on anatomic criteria. Positron emission tomography (PET) with 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) provides useful functional information but requires anatomical correlation to localise lesions accurately. We have prospectively compared the accuracy of combined PET/CT with that of CT and PET alone at initial staging in lymphoma patients. Forty-seven newly diagnosed patients were evaluated. PET/CT was superior compared with CT and PET in nodal evaluation and detection of extranodal disease. Using a staging algorithm with PET/CT resulted in the disease stage being increased in 11 of 47 patients (10 NHL and 1 HL) (McNemar test P = 0.012). Therefore, a different treatment strategy based on PET/CT findings was suggested for seven patients (14.8%). PET/CT markedly improves accuracy in the diagnostic work-up of patients with lymphoma. |
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Authors:
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Dolores Hernandez-Maraver; Fernando Hernandez-Navarro; Nieves Gomez-Leon; Juan Coya; Beatriz Rodriguez-Vigil; Rosario Madero; Immaculada Pinilla; Luis M Martin-Curto |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of haematology Volume: 135 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-11 Completed Date: 2006-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 293-302 Citation Subset: IM |
Affiliation:
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Department of Haematology, La Paz University Hospital, Madrid, Spain. hernandezlola@mac.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Algorithms Bone Marrow / pathology Female Fluorodeoxyglucose F18 / diagnostic use Hodgkin Disease / drug therapy, radiography Humans Lymphoma / drug therapy, radiography* Lymphoma, Non-Hodgkin / drug therapy, radiography Male Middle Aged Neoplasm Staging Positron-Emission Tomography / methods* Prospective Studies Radiopharmaceuticals / diagnostic use Tomography, X-Ray Computed / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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