| Positron emission tomography-computed tomography surveillance for the node-positive neck after chemoradiotherapy. | |
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MedLine Citation:
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PMID: 19358193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES/HYPOTHESIS: To review our results with positron emission tomography and computed tomography fusion imaging (PET-CT) surveillance of the postchemoradiotherapy neck in patients with advanced head and neck squamous cell carcinoma. STUDY DESIGN: Retrospective. METHODS: Four hundred twenty-eight patients with advanced head and neck squamous cell carcinoma were treated with nonsurgical therapy from September 2002 to March 2007 and followed with post-treatment PET-CT surveillance of the neck. Fifty-two patients meeting inclusion criteria were analyzed. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT were determined. RESULTS: Ten patients had a positive post-treatment PET-CT for residual neck disease, and 42 patients had negative scans. The NPV and PPV were 100% and 40%, respectively. The sensitivity, specificity, and accuracy were 100%, 87.5%, and 88%, respectively. CONCLUSIONS: Planned neck dissection can be deferred with a negative post-treatment PET-CT. Assuming a complete response at the primary site and a negative PET-CT scan, there may be a role for serial PET-CT surveillance in patients with residual palpable cervical lymphadenopathy. Laryngoscope, 2009. |
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Authors:
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Amy G Rabalais; Rohan Walvekar; Daniel Nuss; Andrew McWhorter; Charles Wood; Robert Fields; Donald E Mercante; Anna M Pou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 119 ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-26 Completed Date: 2009-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 1120-4 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology and Head Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / drug therapy*, pathology, radionuclide imaging, radiotherapy* Combined Modality Therapy Disease Progression Female Fluorodeoxyglucose F18 / diagnostic use Follow-Up Studies Humans Image Enhancement* Image Processing, Computer-Assisted* Lymphatic Metastasis / pathology, radionuclide imaging, radiotherapy* Male Middle Aged Neck Dissection Neoplasm Recurrence, Local / radionuclide imaging* Neoplasm Staging Neoplasm, Residual / radionuclide imaging* Otorhinolaryngologic Neoplasms / drug therapy*, pathology, radionuclide imaging, radiotherapy* Positron-Emission Tomography* Radiotherapy, Conformal Sensitivity and Specificity Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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