Document Detail

Positron emission tomographic evaluations in the diagnosis and therapy of multifocal glioblastoma. Report of a pediatric case.
MedLine Citation:
PMID:  3039475     Owner:  NLM     Status:  MEDLINE    
A pediatric case of multifocal glioblastoma is reported with special reference to positron emission tomography (PET) evaluations in the diagnosis and therapy. A PET scan employing 15O and 18F positron tracers disclosed a right thalamic lesion high in regional cerebral blood flow, cerebral blood volume and metabolic glucose rate, suggesting a malignant tumor. In contrast, a left frontal lesion with low regional cerebral blood flow, cerebral blood volume and metabolic glucose rate was presumed to be rather hypodynamic and hypometabolic. Histological examination of these isolated masses showed both to be glioblastomas, and, as predicted by the PET findings, there were minor histological distinctions. In repeated PET scans following postoperative combined radiochemotherapy, metabolic glucose rate values at the thalamic tumor decreased to about 50% the levels before therapy, although there was no distinguishable change in tumor size on the concurrent computerized tomography scans. This therapeutic efficacy on tumor metabolism was highly consistent with the period of clinical relief.
K Mineura; T Yasuda; M Kowada; T Sakamoto; T Ogawa; F Shishido; K Uemura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neuroscience     Volume:  12     ISSN:  0255-7975     ISO Abbreviation:  Pediatr Neurosci     Publication Date:    1985-1986
Date Detail:
Created Date:  1987-09-02     Completed Date:  1987-09-02     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  8601677     Medline TA:  Pediatr Neurosci     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  208-12     Citation Subset:  IM    
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MeSH Terms
Brain Neoplasms / radionuclide imaging*,  therapy
Combined Modality Therapy
Deoxyglucose / analogs & derivatives,  diagnostic use
Fluorodeoxyglucose F18
Frontal Lobe / radionuclide imaging
Glioblastoma / radionuclide imaging*,  therapy
Organometallic Compounds / diagnostic use
Pentetic Acid / diagnostic use
Technetium Tc 99m Pentetate
Thalamus / radionuclide imaging
Tomography, Emission-Computed*
Reg. No./Substance:
0/Organometallic Compounds; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18; 65454-61-7/Technetium Tc 99m Pentetate; 67-43-6/Pentetic Acid

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