Document Detail


Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy.
MedLine Citation:
PMID:  16360359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial perfusion (MP) may differ in physiologic and pathologic left ventricular hypertrophy (LVH). We compared MP in LVH in elite athletes and patients with hypertension with healthy, age-matched subjects. We included 12 rowers with LVH, 19 patients with hypertension with LVH, and 2 age-matched groups of healthy subjects (n = 11 and n = 12). The left ventricular mass index was determined echocardiographically. MP was measured by N-13 ammonia positron emission tomography. The maximal perfusion and perfusion reserve were studied using dipyridamole, and endothelial function was assessed by a cold pressor test. The degree of LVH was similar in athletes and those with hypertension. Compared with controls, athletes had 20% lower baseline MP (p <0.05), a similar response to the cold pressor test, and a higher perfusion reserve (31%, p <0.05). The patients with hypertension had a 25% higher baseline MP (p <0.05), a reduced increase during the cold pressor test (12% vs 25% in controls, p <0.05), and a reduced perfusion reserve (27% lower, p <0.001). The peak global perfusion (MP x left ventricular mass index) was 62% higher in athletes (p <0.05) than in controls, but the peak global perfusion in patients with hypertension did not differ from that of controls. In conclusion, physiologic LVH in athletes is suited for a high peak workload at the cost of only a small increase in basal myocardial oxygen consumption. In contrast, LVH in the presence of hypertension is a good adaptation to the increased baseline workload with maintained maximal cardiac performance. Endothelial dysfunction may contribute to the reduced perfusion reserve seen in hypertensive LVH.
Authors:
Andreas Kjaer; Christian Meyer; Kristian Wachtell; Michael Hecht Olsen; Hans Ibsen; Lionel Opie; Søren Holm; Birger Hesse
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-10-28
Journal Detail:
Title:  The American journal of cardiology     Volume:  96     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-01-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1692-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet University Hospital, Copenhagen, Denmark. kjaer@mfi.ku.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Coronary Circulation / physiology*
Coronary Vessels / drug effects,  physiopathology
Dipyridamole / administration & dosage,  diagnostic use
Echocardiography
Female
Heart Ventricles / radionuclide imaging*,  ultrasonography
Humans
Hypertension / complications*,  physiopathology
Hypertrophy, Left Ventricular / etiology,  physiopathology,  radionuclide imaging*
Infusions, Intravenous
Male
Middle Aged
Positron-Emission Tomography*
Sports / physiology*
Vasodilation / drug effects,  physiology
Vasodilator Agents / administration & dosage,  therapeutic use
Ventricular Function
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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