| Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy. | |
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MedLine Citation:
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PMID: 16360359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial perfusion (MP) may differ in physiologic and pathologic left ventricular hypertrophy (LVH). We compared MP in LVH in elite athletes and patients with hypertension with healthy, age-matched subjects. We included 12 rowers with LVH, 19 patients with hypertension with LVH, and 2 age-matched groups of healthy subjects (n = 11 and n = 12). The left ventricular mass index was determined echocardiographically. MP was measured by N-13 ammonia positron emission tomography. The maximal perfusion and perfusion reserve were studied using dipyridamole, and endothelial function was assessed by a cold pressor test. The degree of LVH was similar in athletes and those with hypertension. Compared with controls, athletes had 20% lower baseline MP (p <0.05), a similar response to the cold pressor test, and a higher perfusion reserve (31%, p <0.05). The patients with hypertension had a 25% higher baseline MP (p <0.05), a reduced increase during the cold pressor test (12% vs 25% in controls, p <0.05), and a reduced perfusion reserve (27% lower, p <0.001). The peak global perfusion (MP x left ventricular mass index) was 62% higher in athletes (p <0.05) than in controls, but the peak global perfusion in patients with hypertension did not differ from that of controls. In conclusion, physiologic LVH in athletes is suited for a high peak workload at the cost of only a small increase in basal myocardial oxygen consumption. In contrast, LVH in the presence of hypertension is a good adaptation to the increased baseline workload with maintained maximal cardiac performance. Endothelial dysfunction may contribute to the reduced perfusion reserve seen in hypertensive LVH. |
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Authors:
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Andreas Kjaer; Christian Meyer; Kristian Wachtell; Michael Hecht Olsen; Hans Ibsen; Lionel Opie; Søren Holm; Birger Hesse |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-10-28 |
Journal Detail:
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Title: The American journal of cardiology Volume: 96 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-01-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1692-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet University Hospital, Copenhagen, Denmark. kjaer@mfi.ku.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Circulation / physiology* Coronary Vessels / drug effects, physiopathology Dipyridamole / administration & dosage, diagnostic use Echocardiography Female Heart Ventricles / radionuclide imaging*, ultrasonography Humans Hypertension / complications*, physiopathology Hypertrophy, Left Ventricular / etiology, physiopathology, radionuclide imaging* Infusions, Intravenous Male Middle Aged Positron-Emission Tomography* Sports / physiology* Vasodilation / drug effects, physiology Vasodilator Agents / administration & dosage, therapeutic use Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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