Document Detail


Positive troponin-T in noncompaction is associated with neuromuscular disorders and poor outcome.
MedLine Citation:
PMID:  17146603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Though cardiac troponin-T may be positive in hypertrophic and dilated cardiomyopathy, it is not known how often troponin-T is positive in left ventricular hypertrabeculation/ noncompaction (LVHT), an unclassified cardiomyopathy. This retrospective study aimed to assess how often troponin-T is positive in LVHT, is associated with elevated CK, is attributable to cardiac or extra-cardiac causes, in particular neuromuscular disorders (NMDs), or if it is a predictor of poor survival. RESULTS: Among 100 patients, detected over a period of 11 years, troponin-T was determined at least once in 71 (71%) of them. Troponin-T was determined once in 36 patients, twice in 8 cases, three times in 11 patients, and more than three times in 16 cases. Troponin- T was positive at least once in 12 patients (17%). Forty-five of the 71 patients suffered from a NMD (63%). Troponin-T positivity was associated with elevated CK in 6 cases. Troponin-T-positivity was attributable to acute myocardial ischemia in a single case, to chronic renal failure in 5 cases, to dilated cardiomyopathy in 4 cases, to atrial fibrillation in 3 cases, to heart failure in 4 cases, and to NMD in 10 cases. Troponin-T positivity in LVHT patients with NMD was assumed to be due to cardiac involvement in the disease. Among the 22 patients who died during the observational period troponin was determined in 16 and was positive in 4 (25%). CONCLUSIONS: Troponin-T is positive in 17% of the patients with LVHT. Most of these patients suffer from a NMD. Troponin-T positivity in LVHT predicts the presence of NMD and poor survival.
Authors:
J Finsterer; C Stöllberger; W Krugluger
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Publication Detail:
Type:  Journal Article     Date:  2006-12-08
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  96     ISSN:  1861-0684     ISO Abbreviation:  -     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  IM    
Affiliation:
Krankenanstalt Rudolfstiftung, Vienna, Austria. dvarte@aonmail.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Cardiomyopathy, Dilated / complications
Cardiomyopathy, Hypertrophic / complications
Creatine Kinase / blood*
Female
Humans
Hypertrophy, Left Ventricular / blood*,  complications,  diagnosis,  mortality
Male
Middle Aged
Neuromuscular Diseases / blood*,  complications,  diagnosis,  mortality
Predictive Value of Tests
Prognosis
Retrospective Studies
Sensitivity and Specificity
Survival Analysis
Troponin T / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin T; EC 2.7.3.2/Creatine Kinase

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