Document Detail

Positive serum screening for fetal Down syndrome does not predict adverse pregnancy outcome in absence of fetal aneuploidy.
MedLine Citation:
PMID:  9419747     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine whether false-positive maternal serum screening for fetal Down syndrome is predictive of poor pregnancy outcome. METHODS: The pregnancy outcomes of 99 women having positive serum screening for fetal Down syndrome (study group)--based upon maternal serum alpha-fetoprotein (MSAFP), unconjugated estriol (uE3), hCG, and maternal age--were compared to the outcomes of matched control patients having negative serum screening results (control group). The outcome indices analyzed were fetal death, intrauterine growth retardation (IUGR), preeclampsia, and fetal anomalies. RESULTS: Between the study group and the control group, there were no statistically significant differences in pregnancy outcome with respect to fetal death, IUGR, preeclampsia, or fetal anomalies. CONCLUSIONS: Our findings demonstrate no apparent increase in the adverse perinatal outcomes analyzed in women having unexplained positive serum screening for fetal Down syndrome. Although further investigation is needed, these results provide no evidence to support increased antepartum surveillance in such patients.
J S Dungan; L P Shulman; O P Phillips; J L Simpson; N L Meyer; C Grevengood; S Elias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  1     ISSN:  1071-5576     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:    1994 Jan-Mar
Date Detail:
Created Date:  1998-02-02     Completed Date:  1998-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA.
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MeSH Terms
Case-Control Studies
Congenital Abnormalities / diagnosis
Down Syndrome / blood*
Fetal Death / diagnosis
Fetal Growth Retardation / diagnosis
Mass Screening / methods*
Maternal Age
Pre-Eclampsia / diagnosis
Predictive Value of Tests
Pregnancy Outcome*
Pregnancy, High-Risk
Prenatal Diagnosis / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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