Document Detail


Positive selection on the killer whale mitogenome.
MedLine Citation:
PMID:  20810427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondria produce up to 95 per cent of the eukaryotic cell's energy. The coding genes of the mitochondrial DNA may therefore evolve under selection owing to metabolic requirements. The killer whale, Orcinus orca, is polymorphic, has a global distribution and occupies a range of ecological niches. It is therefore a suitable organism for testing this hypothesis. We compared a global dataset of the complete mitochondrial genomes of 139 individuals for amino acid changes that were associated with radical physico-chemical property changes and were influenced by positive selection. Two such selected non-synonymous amino acid changes were found; one in each of two ecotypes that inhabit the Antarctic pack ice. Both substitutions were associated with changes in local polarity, increased steric constraints and α-helical tendencies that could influence overall metabolic performance, suggesting a functional change.
Authors:
Andrew D Foote; Phillip A Morin; John W Durban; Robert L Pitman; Paul Wade; Eske Willerslev; M Thomas P Gilbert; Rute R da Fonseca
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Publication Detail:
Type:  Journal Article     Date:  2010-09-01
Journal Detail:
Title:  Biology letters     Volume:  7     ISSN:  1744-957X     ISO Abbreviation:  Biol. Lett.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-05-10     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  116-8     Citation Subset:  IM    
Affiliation:
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Volgade 5-7, 1350 Copenhagen, Denmark. footead@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA, Mitochondrial / genetics*
Gene Expression Regulation / physiology*
Genome*
Selection, Genetic
Whale, Killer / genetics*
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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