Document Detail


Positive relationship between the dosage of pindolol and its antihypertensive effect.
MedLine Citation:
PMID:  6176796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pindolol was given once a day to 15 patients with mild to moderate hypertension to investigate whether once-daily dosage controls blood pressure for 24 h and whether a paradoxical rise in blood pressure occurs with increasing dosage. Placebo and pindolol, 10, 20, and 30 mg, were administered in double-blind or single-blind fashion. Blood pressure and heart rate were determined under identical and strictly standardized conditions 24-26 h after giving the last capsule. Blood pressure levels were significantly lower during all periods of active treatment compared with placebo levels. There was a clear relation between dosage of pindolol and its antihypertensive effect. These results demonstrate the pindolol can be given once daily in the treatment of hypertension and that a paradoxical rise of blood pressure does not occur with dosages up to 30 mg pindolol daily.
Authors:
L Andrén; L Hansson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  4     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1982 Jan-Feb
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Humans
Hypertension / drug therapy*
Pindolol / administration & dosage*,  pharmacology
Chemical
Reg. No./Substance:
13523-86-9/Pindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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