| Positive placental staining for alkaline phosphatase corresponding with extreme elevation of serum alkaline phosphatase during pregnancy. | |
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MedLine Citation:
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PMID: 16924514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental ALP (ALP(h)) is a membrane-anchored, heat-stable enzyme produced by the syncytiotrophoblast. We report a case of a patient presenting in the third trimester with extreme increased levels of ALP(h). A 40-year-old woman, gravida 2, para 1, was admitted to the high risk pregnancy unit at 30 weeks of gestation for evaluation of an incidental finding of marked isolated elevation in serum ALP(h). Blood tests obtained at admission revealed a marked elevation of serum ALP level up to 1,194 u/l (reference 35-104 u/l). At 36 weeks of gestation, the patient was admitted with preterm premature rupture of membranes. Due to breech presentation, a cesarean delivery was performed. An immunoperoxidase stain was done for placental alkaline phosphatase, which was positive in the majority of chorionic trophoblastic cells. No evidence of inflammation was detected in the placental chorionic plate. Thus, isolated elevation in placental ALP may be linked to a subsequent preterm delivery. |
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Authors:
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Asher Bashiri; Ohad Katz; Esther Maor; Eyal Sheiner; Izak Pack; Moshe Mazor |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-08-22 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 275 ISSN: 0932-0067 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-06 Completed Date: 2007-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel. abashiri@bgumail.bgu.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkaline Phosphatase / analysis*, blood Female Fetal Membranes, Premature Rupture / blood* Humans Placenta / chemistry* Pregnancy Pregnancy Trimester, Third Premature Birth / blood* |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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