Document Detail


Positive and negative regulation of telomerase access to the telomere.
MedLine Citation:
PMID:  10984427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The protective caps on chromosome ends - known as telomeres - consist of DNA and associated proteins that are essential for chromosome integrity. A fundamental part of ensuring proper telomere function is maintaining adequate length of the telomeric DNA tract. Telomeric repeat sequences are synthesized by the telomerase reverse transcriptase, and, as such, telomerase is a central player in the maintenance of steady-state telomere length. Evidence from both yeast and mammals suggests that telomere-associated proteins positively or negatively control access of telomerase to the chromosome terminus. In yeast, positive regulation of telomerase access appears to be achieved through recruitment of the enzyme by the end-binding protein Cdc13p. In contrast, duplex-DNA-binding proteins assembled along the telomeric tract exert a feedback system that negatively modulates telomere length by limiting the action of telomerase. In mammalian cells, and perhaps also in yeast, binding of these proteins probably promotes a higher-order structure that renders the telomere inaccessible to the telomerase enzyme.
Authors:
S K Evans; V Lundblad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  113 Pt 19     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-15     Completed Date:  2000-11-30     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3357-64     Citation Subset:  IM    
Affiliation:
Department of Molecular and Human Genetics, and Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030 USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle
Cyclin B / metabolism
DNA / metabolism*
DNA-Binding Proteins / metabolism
Fungal Proteins / metabolism
Macromolecular Substances
Models, Biological
Saccharomyces cerevisiae Proteins*
Telomerase / metabolism*
Telomere / metabolism*,  ultrastructure
Chemical
Reg. No./Substance:
0/Cyclin B; 0/DNA-Binding Proteins; 0/Fungal Proteins; 0/Macromolecular Substances; 0/Saccharomyces cerevisiae Proteins; 9007-49-2/DNA; EC 2.7.7.49/EST1 protein, S cerevisiae; EC 2.7.7.49/Telomerase

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