Document Detail


Positive- and negative-ion mass spectrometry of butyrophenones.
MedLine Citation:
PMID:  3782382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positive-ion electron-impact (EI), positive-ion chemical ionization (CI) and medium-pressure negative-ion CI mass spectra of ten butyrophenones are presented. Low-pressure (0.01 Torr) negative CI spectra are also presented for some compounds. In the positive EI mode, a peak at m/z 42, which corresponded to the propyl group, appeared for all compounds; a peak at m/z 123 was also common to all compounds except for the two with a bis(fluorophenyl) group. Molecular ions were generally very small or missing in the positive EI mode. In the positive CI mode, strong [M+H]+ quasi-molecular peaks generally appeared together with [M+C2H5]+ peaks; [M-F]+ peaks appeared in many compounds and [M-OH]+ peaks also appeared for compounds having a hydroxypiperidinyl group. In the negative CI mode with a 1 Torr chamber pressure, their spectra were generally simple with [M-H]- quasi-molecular ions; anions of liberated halogens were not observed except for bromine at this pressure. In the negative CI mode at low pressure (0.01 Torr), some fragment peaks in the lower mass range appeared in addition to the quasi-molecular ions; halogen peaks (m/z 19 or 35) and anions at m/z 95, which corresponded to the fluorophenyl group, appeared in most spectra recorded at this pressure. An procedure for the extraction of butyrophenones from human urine and plasma and their separation by gas chromatography was also developed to serve for their identification in forensic science practice.
Authors:
H Hattori; O Suzuki; H Brandenberger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  382     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-22     Completed Date:  1987-01-22     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Butyrophenones / analysis*,  blood,  urine
Chromatography, Gas
Humans
Mass Spectrometry
Chemical
Reg. No./Substance:
0/Butyrophenones

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