| Positive inotropic and negative lusitropic effects of endothelin receptor agonism in vivo. | |
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MedLine Citation:
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PMID: 15951343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endothelin (ET) system is involved in the regulation of myocardial function in health as well as in several diseases, such as congestive heart failure, myocardial infarction, and septic myocardial depression. Conflicting results have been reported regarding the acute contractile properties of ET-1. We therefore investigated the effects of intracoronary infusions of ET-1 and of the selective ET(B) receptor-selective agonist sarafotoxin 6c with increasing doses in anesthetized pigs. Myocardial effects were measured through analysis of the left ventricular pressure-volume relationship. ET-1 elicited increases in the myocardial contractile status (end-systolic elastance value of 0.94 +/- 0.11 to 1.48 +/- 0.23 and preload recruitable stroke work value of 68.7 +/- 4.7 to 83.4 +/- 7.2) that appear to be mediated through ET(A) receptors, whereas impairment in left ventricular isovolumic relaxation (tau = 41.5 +/- 1.4 to 58.1 +/- 5.0 and t(1/2) = 23.0 +/- 0.7 to 30.9 +/- 2.6, where tau is the time constant for pressure decay and t(1/2) is the half-time for pressure decay) was ET(B) receptor dependent. In addition, intravenous administration of ET-1 impaired ventricular relaxation but had no effect on contractility. Intracoronary sarafotoxin 6c administration caused impairments in left ventricular relaxation (tau from 43.3 +/- 1.8 to 54.4 +/- 3.4) as well as coronary vasoconstriction. In conclusion, ET-1 elicits positive inotropic and negative lusitropic myocardial effects in a pig model, possibly resulting from ET(A) and ET(B) receptor activation, respectively. |
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Authors:
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D Konrad; A Oldner; M Wanecek; A Rudehill; E Weitzberg; B Biber; G Johansson; S Häggmark; M Haney |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-10 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 289 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-15 Completed Date: 2005-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1702-9 Citation Subset: IM |
Affiliation:
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Department of Surgical Sciences, Section for Anaesthesiology and Intensive Care, Karolinska Institute, Stockholm, Sweden. david.konrad@kirurgi.ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Cardiotonic Agents / pharmacology* Coronary Circulation / drug effects Diastole / drug effects Endothelin-1 / blood, pharmacology* Female Heart / drug effects*, physiology Injections, Intravenous Myocardial Contraction / drug effects Oxygen / metabolism Receptor, Endothelin B / antagonists & inhibitors Receptors, Endothelin / agonists* Sus scrofa Vasoconstrictor Agents / pharmacology Ventricular Pressure / drug effects Viper Venoms / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Endothelin-1; 0/Receptor, Endothelin B; 0/Receptors, Endothelin; 0/Vasoconstrictor Agents; 0/Viper Venoms; 0/sarafotoxins s6; 7782-44-7/Oxygen |
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