| Positive inotropic effects of hydralazine in human subjects: comparison with prazosin in the setting of congestive heart failure. | |
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MedLine Citation:
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PMID: 7446418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydralazine possesses positive inotropic properties in animal model preparations. To determine whether this vasodilator elicits a positive inotropic response in the failing human ventricle, hydralazine, 75 or 100 mg, was administered orally to 14 patients with left ventricular dysfunction and congestive heart failure; the results were compared with those of first-dose prazosin at 5 and 10 mg. The duration of the preejection period and the isovolumic developed pressure/duration of isovolumic contraction (delta P/delta t) were used as indexes of inotropy. Prazosin did not effect a significant response in the duration of the preejection period or in the delta P/delta t. Hydralazine significantly shortened the preejection period and increased the delta P/delta t over 8 hours after administration; these data suggest that hydralazine elicits a positive inotropic response in the failing human ventricle. |
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Authors:
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C V Leier; C E Desch; R D Magorien; D W Triffon; D V Unverferth; H Boudoulas; R P Lewis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 46 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-02-19 Completed Date: 1981-02-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1039-44 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Drug Heart Failure / drug therapy* Heart Rate / drug effects Humans Hydralazine / therapeutic use* Myocardial Contraction / drug effects* Prazosin / therapeutic use* Pulmonary Wedge Pressure / drug effects Quinazolines / therapeutic use* Stroke Volume / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Quinazolines; 19216-56-9/Prazosin; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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