Document Detail


Positive inotropic effect of some taurine-related compounds on guinea-pig ventricular strips perfused with low calcium medium.
MedLine Citation:
PMID:  3720833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Taurine exerts a positive inotropic effect at a low calcium concentration. Of the compounds chemically related to taurine only L-cysteic and 2-aminobenzenesulfonic acid mimic taurine action. Their effect is concentration-dependent and not linked to the restoration of taurine tissue concentration in guinea-pig ventricular strips. Our data demonstrate that: (1) carbon chain length between amino and sulfonic groups is a crucial factor in the development of activity. (2) Substitution of the sulfonic group with other acid functions such as the substitution of the primary amino group or the introduction of the -COOH group onto the beta-carbon brings about a lack of activity.
Authors:
F Franconi; P Failli; I Stendardi; R Matucci; F Bennardini; C Baccaro; A Giotti
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  124     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / physiology*
Cysteic Acid / metabolism
Guinea Pigs
Male
Myocardial Contraction / drug effects*
Myocardium / metabolism
Stimulation, Chemical
Taurine / analogs & derivatives*,  metabolism,  pharmacology*
Time Factors
Chemical
Reg. No./Substance:
107-35-7/Taurine; 13100-82-8/Cysteic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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