Document Detail


Positive imaging of venous thrombi and thromboemboli with Ga-67 DFO-DAS-fibrinogen.
MedLine Citation:
PMID:  3391213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A newly developed thrombus imaging agent, 67Ga-DFO-DAS-fibrinogen (67Ga-fibrinogen), was used for 22 studies in 20 cases of suspected deep venous thrombosis. Increased accumulation of 67Ga-fibrinogen in venous thrombi was depicted at 48 h after injection in 10 of the 15 cases (10 of 17 studies) who showed abnormal findings in radionuclide venography. A hot spot in the lung emboli was visualized in two cases. Seven of the eight cases having anticoagulant therapy showed increased 67Ga-fibrinogen uptake, while follow-up 67Ga-fibrinogen scintigraphy after the administration of heparin and urokinase did not reveal an abnormal hot spot in one case. 67Ga-fibrinogen can be made available simply by adding 67Ga solution to a vial containing fibrinogen-DAS-DFO conjugate. In conclusion, 67Ga-fibrinogen is considered to be a promising agent for detecting active venous thrombi and to assess the effect of anticoagulant therapy.
Authors:
K Yamamoto; M Senda; T Fujita; K Kumada; K Fukui; Y Yonekura; A Yokoyama; K Torizuka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  14     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1988  
Date Detail:
Created Date:  1988-08-19     Completed Date:  1988-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
Affiliation:
Department of Radiology and Nuclear Medicine, Kyoto University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Deferoxamine / diagnostic use*
Female
Fibrinogen / diagnostic use*
Gallium Radioisotopes / diagnostic use*
Humans
Male
Middle Aged
Pulmonary Embolism / radionuclide imaging*
Starch / analogs & derivatives*,  diagnostic use
Thrombophlebitis / radionuclide imaging*
Chemical
Reg. No./Substance:
0/Gallium Radioisotopes; 0/gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate; 70-51-9/Deferoxamine; 9001-32-5/Fibrinogen; 9005-25-8/Starch

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