| Positive-feedback loops in cell cycle progression. | |
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MedLine Citation:
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PMID: 19818353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A positive-feedback loop is a simple motif that is ubiquitous to the modules and networks that comprise cellular signaling systems. Signaling behaviors that are synonymous with positive feedback include amplification and rapid switching, maintenance, and the coherence of outputs. Recent advances have been made towards understanding how positive-feedback loops function, as well as their mechanistic basis in controlling eukaryotic cell cycle progression. Some of these advances will be reviewed here, including: how cyclin controls passage through Start and maintains coherence of G1/S regulon expression in yeast; how Polo-like kinase 1 activation is driven by Bora and Aurora A, and its expression is stimulated by Forkhead Box M1 in mammalian cells; and how some of the various dynamic behaviors of spindle assembly and anaphase onset can be produced. |
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Authors:
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Joseph R Pomerening |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-10-07 |
Journal Detail:
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Title: FEBS letters Volume: 583 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2009-12-03 Revised Date: 2011-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3388-96 Citation Subset: IM |
Affiliation:
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Department of Biology, Interdisciplinary Program in Biochemistry, Indiana University, 212 S. Hawthorne Drive Simon Hall Room 043F, Bloomington, IN 47405-7003, United States. jpomeren@indiana.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* / genetics Feedback, Physiological* / genetics Gene Expression Regulation Humans Mitosis Regulon / genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM086526-01A1/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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