Document Detail


Positive exercise thallium-201 test responses in patients with less than 50% maximal coronary stenosis: angiographic and clinical predictors.
MedLine Citation:
PMID:  3966399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence and causes of abnormal thallium-201 (TI-201) myocardial perfusion studies in the absence of significant coronary artery disease were examined. The study group consisted of 100 consecutive patients undergoing exercise TI-201 testing and coronary angiography who were found to have maximal coronary artery diameter narrowing of less than 50%. Maximal coronary stenosis ranged from 0 to 40%. The independent and relative influences of patient clinical, exercise and angiographic data were assessed by logistic regression analysis. Significant predictors of a positive stress TI-201 test result were: (1) percent maximal coronary stenosis (p less than 0.0005), (2) propranolol use (p less than 0.01), (3) interaction of propranolol use and percent maximal stenosis (p less than 0.005), and (4) stress-induced chest pain (p = 0.05). No other patient variable had a significant influence. Positive TI-201 test results were more common in patients with 21 to 40% maximal stenosis (59%) than in patients with 0 to 20% maximal stenosis (27%) (p less than 0.01). Among patients with 21 to 40% stenosis, a positive test response was more common when 85% of maximal predicted heart rate was achieved (75%) than when it was not (40%) (p less than 0.05). Of 16 nonapical perfusion defects seen in patients with 21 to 40% maximal stenosis, 14 were in the territory that corresponded with such a coronary stenosis. Patients taking propranolol were more likely to have a positive TI-201 test result (45%) than patients not taking propranolol (22%) (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K A Brown; M Osbakken; C A Boucher; H W Strauss; G M Pohost; R D Okada
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  55     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-01-29     Completed Date:  1985-01-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Coronary Angiography
Coronary Disease / drug therapy,  radiography,  radionuclide imaging*
Exercise Test
Female
Heart / radionuclide imaging*
Humans
Male
Propranolol / pharmacology,  therapeutic use
Radioisotopes / diagnostic use*
Thallium / diagnostic use*
Grant Support
ID/Acronym/Agency:
HL 07416/HL/NHLBI NIH HHS; HL 21751/HL/NHLBI NIH HHS; HL 26215/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Radioisotopes; 525-66-6/Propranolol; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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