Document Detail

Positive end expiratory pressure: effects on lung mechanics of premature lambs.
MedLine Citation:
PMID:  359057     Owner:  NLM     Status:  MEDLINE    
Pulmonary mechanics were determined at 0, 3, 6, and 10 cm H2O positive and expiratory pressure (PEEP) in premature lambs at a mean gestational age of 134 days. Functional residual capacity increased (p less than 0.005) by 7% (1.6 ml/kg) per cm H2O PEEP. Dynamic lung compliance and specific compliance significantly decreased by 10% (0.11 ml/cm H2O/kg) and 9% (0.0051 l/cm H2O) per cm H2O PEEP, respectively, for PEEP above 3 cm H2O level. Inspiratory lung resistance increased significantly (p less than 0.05) only between 0 and 6 cm H2O PEEP while expiratory lung resistance increased (p less than 0.05) between 0 cm H2O PEEP and all higher levels. The data suggest that PEEP in excess of 3 cm H2O produces undesirable effects on lung mechanics in premature lambs. These results may be important in predicting contraindications and potential complications of positive pressure breathing in the newborn.
T H Shaffer; P A Koen; G D Moskowitz; J D Ferguson; M Delivoria-Papadopoulos
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  34     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology*
Functional Residual Capacity
Gestational Age
Infant, Newborn
Lung Compliance
Lung Volume Measurements
Positive-Pressure Respiration*
Respiratory Distress Syndrome, Newborn / therapy

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