Document Detail

Positive end expiratory pressure as a method for preventing acute mountain sickness.
MedLine Citation:
PMID:  9459518     Owner:  NLM     Status:  MEDLINE    
In order to study the use of positive end expiratory pressure (PEEP) to prevent acute mountain sickness (AMS), 22 subjects were exposed randomly to 8-h hypobaric hypoxia in a hypobaric chamber (4500 m, 589 hPa, 22 degrees C) once being administered 5-cm H2O PEEP and once without. The prevention of AMS by PEEP was evaluated by scoring AMS according to the Lake Louise system (self-report questionnaire and clinical assessment) throughout the experiment with O2 saturation (SO2) and heart rate measurements being made. Arterial blood analyses (partial pressures of arterial O2 and CO2, PaO2, PaCO2, and pH) were made at the end of the exposure. Results showed decreased AMS scores with PEEP at the end of the 8-h hypoxia [1.50 (SEM 1.32) vs 3.23 (SEM 2.07), P < 0.01 for self-report plus clinical assessment scores] with a lower prevalence (23% vs 55%, P < 0.01). The SO2, PaO2, PaCO2 and HCO3- did not change significantly. However, a smaller increase in arterial pH [7.47 (SEM 0.02) vs 7.50 (SEM 0.02), P < 0.05] was observed with PEEP, attesting a lesser alkalosis. Moreover, heart rate increased with PEEP (P < 0.05). In conclusion, this study would suggest that a 5-cm H2O PEEP may help decrease AMS scores at the end of an 8-h exposure to hypoxia in a hypobaric chamber. Such a method could be used to prevent AMS in such experimental conditions without adverse effects.
G Savourey; R Caterini; J C Launay; A Guinet; Y Besnard; A M Hanniquet; J Bittel
Related Documents :
6387528 - Use of high frequency jet ventilation during mechanical hyperventilation to reduce intr...
15352958 - Oleic acid lung injury: a morphometric analysis using computed tomography.
7000438 - Pulmonary venous admixture during mechanical ventilation with varying fio2 and peep.
11208628 - Best compliance during a decremental, but not incremental, positive end-expiratory pres...
24739538 - Efficacy and safety of 10-mg azilsartan compared with 8-mg candesartan cilexetil in jap...
7575798 - Percutaneous needle cricothyroidotomy with repetitive airway obstruction.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  77     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1998  
Date Detail:
Created Date:  1998-03-06     Completed Date:  1998-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM; S    
Unite de Thermophysiologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Altitude Sickness / prevention & control*
Atmospheric Pressure
Carbon Dioxide / blood
Heart Rate
Hydrogen-Ion Concentration
Oxygen / blood
Positive-Pressure Respiration*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of decreased plasma glutamine concentrations on peripheral lymphocyte proliferation in rats.
Next Document:  Pre-adaptation, adaptation and de-adaptation to high altitude in humans: hormonal and biochemical ch...