| Positive effects on hematopoiesis in patients with myelodysplastic syndrome receiving deferasirox as oral iron chelation therapy: A brief review. | |
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MedLine Citation:
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PMID: 21185078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Iron overload is a frequent consequence in transfusion-dependent myelodysplastic syndromes (MDSs), which often requires iron chelation therapy (ICT). Interestingly, ICT may sometimes induce a hematologic improvement that leads to significant reduction or complete interruption of blood transfusions. This phenomenon has been recently described in MDS treated with the new oral chelator deferasirox. Here we briefly review the literature about this phenomenon and discuss the possible biological mechanisms underlying hematologic effects of deferasirox in MDS, starting from a new paradigmatic case in whom both hemoglobin level and platelet count improved, inducing transfusion-independence, soon after starting the treatment with deferasirox. |
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Authors:
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Roberto Guariglia; Maria Carmen Martorelli; Oreste Villani; Giuseppe Pietrantuono; Giovanna Mansueto; Fiorella D'Auria; Vitina Grieco; Gabriella Bianchino; Rosa Lerose; Giovanni Battista Bochicchio; Pellegrino Musto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-22 |
Journal Detail:
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Title: Leukemia research Volume: - ISSN: 1873-5835 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Onco-Hematology, Centro di Riferimento Oncologico della Basilicata, IRCCS, Via San Pio 1, 85028 Rionero in Vulture (PZ), Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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