Document Detail


Positive effects of anabolic steroids, vitamin D and calcium on muscle mass, bone mineral density and clinical function after a hip fracture. A randomised study of 63 women.
MedLine Citation:
PMID:  12043767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 63 women who had an operation for a fracture of the hip was randomly allocated to one year of treatment either with anabolic steroids, vitamin D and calcium (anabolic group) or with calcium only (control group). The thigh muscle volume was measured by quantitative CT. The bone mineral density of the hip, femur and tibia was assessed by quantitative CT and dual-energy x-ray absorptiometry and of the heel by quantitative ultrasound. Quantitative CT showed that the anabolic group did not lose muscle volume during the first 12 months whereas the control group did (p<0.01). There was less bone loss in the proximal tibia in the anabolic group than in the control group. The speed of gait and the Harris hip score were significantly better in the anabolic group after six and 12 months. Anabolic steroids, even in this moderate dose, given in combination with vitamin D and calcium had a beneficial effect on muscle volume, bone mineral density and clinical function in this group of elderly women.
Authors:
M Hedström; K Sjöberg; E Brosjö; K Aström; H Sjöberg; N Dalén
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  84     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-07-02     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  497-503     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedics, Karolinska Institute and Danderyd Hospital, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anabolic Agents / therapeutic use*
Bone Density / drug effects*
Calcium / therapeutic use*
Female
Hip Fractures / rehabilitation*
Humans
Muscle, Skeletal / anatomy & histology,  drug effects*
Recovery of Function
Vitamin D / therapeutic use*
Chemical
Reg. No./Substance:
0/Anabolic Agents; 1406-16-2/Vitamin D; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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