Document Detail

Positive correlation between probucol in low density lipoprotein and LDL-lowering.
MedLine Citation:
PMID:  8299667     Owner:  NLM     Status:  MEDLINE    
The relationship between the content of probucol in plasma and lipid lowering was studied after administration of probucol. The study group consisted of 44 patients with Type II hyperlipidaemia (mean age 56 y). Total cholesterol level was decreased from 293 to 232 mg.dl-1 by the administration of probucol. The plasma probucol concentration was 2.03 mg.dl-1 after 4 weeks of administration of 500 mg b.d. Although there was no relationship between the change in total cholesterol and the plasma probucol, a linear relation was observed between the decrease in LDL-cholesterol concentration and the probucol concentration in LDL. Neither the VLDL nor the HDL-probucol content were related to the magnitude of the decrease in lipoprotein cholesterol. The present study has demonstrated that an increase in the probucol content in LDL was associated with a decrease in plasma LDL-cholesterol.
M Shinomiya; K Shirai; Y Saito; S Yoshida
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  45     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-07     Completed Date:  1994-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  IM    
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
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MeSH Terms
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood*
Hyperlipidemias / blood
Lipoproteins, LDL / blood*,  chemistry
Middle Aged
Probucol / blood*,  pharmacology
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 23288-49-5/Probucol; 57-88-5/Cholesterol

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