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Positive correlation between chronic hyperglycemia and serum fetuin-A levels in middle-aged and elderly Chinese.
MedLine Citation:
PMID:  23190703     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background:  The aim of the present study was to evaluate the association between HbA1c and serum fetuin-A levels in middle-aged and elderly Chinese. Methods:  A total of 3790 subjects (1519 men; 2271 women) aged ≥40 years were enrolled in this cross-sectional study in the Songnan community of Baoshan District, Shanghai, China. HbA1c levels were used to determine the presence of chronic hyperglycemia. Subjects were divided into three groups based on HbA1c levels: <6.5%, 6.5% ≤ HbA1c < 7.0%, and HbA1c ≥ 7.0%. "Elevated" fetuin-A levels were defined as serum levels in the upper quartile (i.e. ≥367.39 mg/L). Results:  Mean serum fetuin-A levels were higher in subjects with HbA1c ≥ 7.0% compared with those in whom HbA1c was <6.5% (309.32 vs 290.83 mg/L, respectively). Multivariate linear regression analysis revealed a significant positive correlation between HbA1c and serum fetuin-A levels (β = 0.07; SE = 0.03; P = 0.04). After adjustment for possible confounders, an increased percentage of subjects with elevated fetuin-A levels was found in the group with HbA1c ≥ 7.0% compared with the group in which HbA1c was <6.5% (odds ratio 1.38; 95% confidence interval 1.09-1.74). Interactions were found between HbA1c and both insulin resistance and the urinary albumin-to-creatinine ratio for the percentage of elevated fetuin-A levels (P(interaction)  = 0.002 and 0.05, respectively). Conclusions:  In Chinese adults, a positive correlation was found between chronic hyperglycemia and serum fetuin-A levels. Further research into the mechanisms underlying fetuin-A regulation is needed to identify potential drug targets.
Authors:
Yu Liu; Min Xu; Yu Xu; Mian Li; Tiange Wang; Yuhong Chen; Yufang Bi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of diabetes     Volume:  4     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  351-8     Citation Subset:  IM    
Copyright Information:
© 2012 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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