Document Detail

Positive correlation of CRP and fibrinogen levels as cardiovascular risk factors in early stage of continuous ambulatory peritoneal dialysis patients.
MedLine Citation:
PMID:  18300125     Owner:  NLM     Status:  MEDLINE    
We aimed to study the relationship between the C-reactive protein (CRP), albumin, and fibrinogen as cardiovascular risk factors in continuous ambulatory peritoneal dialysis (CAPD) patients, in the early stage of their therapy. The study included 21 CAPD patients as the study group (SG) and age- and sex-matched 21 healthy patients as the control group (CG). History and physical exam data were obtained for all cases, and demographic baseline characteristics were taken. Twelve-hour fasting serum levels of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, total protein, albumin, hemoglobin, CRP, and fibrinogen were obtained. There was no statistically significant difference between the SG and CG in baseline characteristics, including age, sex, body mass index (BMI), smoking, and family history of cardiovascular disease. However, diabetes mellitus (DM) and hypertension (HTN) were significantly more common among the study group. The average total protein, albumin, and hemoglobin levels were significantly lower, and the CRP and fibrinogen levels were significantly higher (p < 0.001) in the SG. A positive correlation was seen (r = 0.443, p < 0.05) among CRP and fibrinogen levels in SG. There was no correlation among the other parameters in SG. For CG, there was no correlation seen for any studied parameters. When patients with and without cardiovascular disease (CVD) were compared, no correlation was seen between CRP and other parameters. A positive correlation of CRP and fibrinogen levels as cardiovascular risk factors was shown in early stage of CAPD patients. The CAPD patients with elevated levels of CRP and fibrinogen should receive close follow-up for cardiovascular disease prevention.
Ishak Ozel Tekin; Bekir Pocan; Ali Borazan; Edip Ucar; Guven Kuvandik; Sevil Ilikhan; Nejat Demircan; Cahit Ozer; Sinan Kadayifci
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  30     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-05-13     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Department of Immunology, Zonguldak Karaelmas University, The School of Medicine, Zonguldak, Turkey.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
C-Reactive Protein / analysis*
Cardiovascular Diseases / diagnosis*,  epidemiology,  etiology*,  metabolism
Case-Control Studies
Cholesterol, HDL / analysis
Cholesterol, LDL / analysis
Confidence Intervals
Coronary Disease / diagnosis,  epidemiology,  etiology
Fibrinogen / analysis*
Follow-Up Studies
Kidney Failure, Chronic / complications,  diagnosis,  therapy*
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*,  methods
Reference Values
Risk Factors
Severity of Illness Index
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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