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Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults.
MedLine Citation:
PMID:  23959257     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if urinary levels of the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine (AAMA) and the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) are associated. The mean (SD) AAMA and 8-OHdG were 76.54 (76.42)μg/L and 3.48 (2.37)μg/L, respectively. In linear regression analyses, a 1-unit increase in natural log AAMA was significantly associated with an increase in natural log 8-OHdG (μg/g creatinine) (β=0.044, SE=0.019, P=0.020) after controlling for covariates. Subpopulation analyses showed AAMA and 8-OHdG were significantly associated with males, adolescents, non-current smokers, without alcohol consumption, subjects, body mass index ≥24, and homeostasis model assessment of insulin resistance score ≥0.9. In conclusion, higher urinary AAMA concentrations were associated with increased levels of urinary 8-OHdG in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and oxidative stress.
Authors:
Chien-Yu Lin; Hui-Ling Lee; Yu-Chuan Chen; Guang-Wen Lien; Lain-Yu Lin; Li-Li Wen; Chien-Chang Liao; Kuo-Liong Chien; Fung-Chang Sung; Pau-Chung Chen; Ta-Chen Su
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-30
Journal Detail:
Title:  Journal of hazardous materials     Volume:  261C     ISSN:  1873-3336     ISO Abbreviation:  J. Hazard. Mater.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422688     Medline TA:  J Hazard Mater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  372-377     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
Affiliation:
Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.
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