| Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension. | |
| | |
MedLine Citation:
|
PMID: 12219870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and endothelial function. METHODS: A total of 44 newly diagnosed, untreated hypertensive patients, who were free of diabetes mellitus and coronary artery disease, underwent M-mode analysis, second-harmonic Doppler echocardiographic assessment of CFR (dipyridamole infusion 0.56 mg/kg intravenously in four patients), determination of circulating free IGF-1, and insulin resistance. Based on CFR levels, hypertensive subjects were divided into two groups: 18 with normal CFR (> or = 2) and 26 with impaired CFR (<2). RESULTS: Patients with normal CFR had lower diastolic blood pressure, heart rate, and LV mass index but higher free circulating IGF-I than patients with reduced CFR (P < .001). Insulin resistance was not significantly different between the two groups. In a first multilinear regression analysis that included demographic and echocardiographic variables, insulin resistance was independently associated with CFR (standardized beta coefficient = -0.31, P < .05) in the overall population. However, in a subsequent model which included also IGF-1, the relationship between insulin resistance and CFR disappeared, whereas IGF-1 was the main independent determinant of CFR (beta = 0.51, P < .0002). CONCLUSIONS: Free IGF-1 circulating levels are independently associated with CFR in hypertensive individuals free of overt coronary artery disease. A possible beneficial effect exerted by IGF-1 on coronary blood flow may be supposed in arterial hypertension. |
| | |
Authors:
|
Maurizio Galderisi; Pio Caso; Silvana Cicala; Luigi De Simone; Michelangela Barbieri; Giovanni Vitale; Oreste de Divitiis; Giuseppe Paolisso |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of hypertension Volume: 15 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-09-10 Completed Date: 2003-04-30 Revised Date: 2009-02-24 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 766-72 Citation Subset: IM |
Affiliation:
|
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity Body Mass Index Coronary Circulation / physiology* Echocardiography Electrocardiography Female Heart Rate / physiology Humans Hypertension / blood, physiopathology*, ultrasonography Insulin-Like Growth Factor I / physiology* Male Middle Aged Regression Analysis Ventricular Function, Left / physiology |
| Chemical | |
Reg. No./Substance:
|
67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transforming growth factor-beta1 levels in hypertensive patients: association with body mass index a...
Next Document: Excess dietary glucose alters renal function before increasing arterial pressure and inducing insuli...