| Positive action of propionyl-L-carnitine on mechanical performance of papillary muscle from Syrian hamsters with hereditary dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 8991805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Propionyl-L-carnitine has been shown to exert a beneficial effect on cardiac function in different experimental models of cardiomyopathy in the rat, most likely by improving cardiac metabolism and energy production. We have previously shown that, in a strain of hamsters with hereditary dilated cardiomyopathy (BIO TO.2), the mechanical activity of papillary muscle (length-tension, velocity of shortening, shortening, work and power relationship) is significantly depressed when compared to the same parameter in normal hamsters (BIO F1.B). The repeated oral treatment with propionyl-L-carnitine (60 mg/kg per os for 7 weeks) to BIO TO.2 hamsters had a significant positive inotropic effect, as indicated by an increase in developed tension up to the levels observed in papillary muscles from normal hamsters. This action is most likely associated with metabolic effects similar to those observed in rats. |
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Authors:
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P Maresca; R Mancinelli; N Corsico; E Arrigoni-Martelli; E Manni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 287 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1997-01-13 Completed Date: 1997-01-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 303-7 Citation Subset: IM |
Affiliation:
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Dipartimento di Farmacologia, Sigma-Tau S.p.A., Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Analysis of Variance Animals Biomechanics Cardiomyopathy, Dilated / drug therapy* Cardiotonic Agents / administration & dosage, pharmacology, therapeutic use* Carnitine / administration & dosage, analogs & derivatives*, pharmacology, therapeutic use Cricetinae Disease Models, Animal Genetic Diseases, Inborn / drug therapy Male Mesocricetus Myocardial Contraction / drug effects* Papillary Muscles / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 17298-37-2/propionylcarnitine; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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