Document Detail

Positive action of propionyl-L-carnitine on mechanical performance of papillary muscle from Syrian hamsters with hereditary dilated cardiomyopathy.
MedLine Citation:
PMID:  8991805     Owner:  NLM     Status:  MEDLINE    
Propionyl-L-carnitine has been shown to exert a beneficial effect on cardiac function in different experimental models of cardiomyopathy in the rat, most likely by improving cardiac metabolism and energy production. We have previously shown that, in a strain of hamsters with hereditary dilated cardiomyopathy (BIO TO.2), the mechanical activity of papillary muscle (length-tension, velocity of shortening, shortening, work and power relationship) is significantly depressed when compared to the same parameter in normal hamsters (BIO F1.B). The repeated oral treatment with propionyl-L-carnitine (60 mg/kg per os for 7 weeks) to BIO TO.2 hamsters had a significant positive inotropic effect, as indicated by an increase in developed tension up to the levels observed in papillary muscles from normal hamsters. This action is most likely associated with metabolic effects similar to those observed in rats.
P Maresca; R Mancinelli; N Corsico; E Arrigoni-Martelli; E Manni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  287     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-13     Completed Date:  1997-01-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Dipartimento di Farmacologia, Sigma-Tau S.p.A., Rome, Italy.
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MeSH Terms
Administration, Oral
Analysis of Variance
Cardiomyopathy, Dilated / drug therapy*
Cardiotonic Agents / administration & dosage,  pharmacology,  therapeutic use*
Carnitine / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Disease Models, Animal
Genetic Diseases, Inborn / drug therapy
Myocardial Contraction / drug effects*
Papillary Muscles / drug effects*,  physiology
Reg. No./Substance:
0/Cardiotonic Agents; 17298-37-2/propionylcarnitine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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