Document Detail


Positive action of propionyl-L-carnitine on mechanical performance of papillary muscle from Syrian hamsters with hereditary dilated cardiomyopathy.
MedLine Citation:
PMID:  8991805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Propionyl-L-carnitine has been shown to exert a beneficial effect on cardiac function in different experimental models of cardiomyopathy in the rat, most likely by improving cardiac metabolism and energy production. We have previously shown that, in a strain of hamsters with hereditary dilated cardiomyopathy (BIO TO.2), the mechanical activity of papillary muscle (length-tension, velocity of shortening, shortening, work and power relationship) is significantly depressed when compared to the same parameter in normal hamsters (BIO F1.B). The repeated oral treatment with propionyl-L-carnitine (60 mg/kg per os for 7 weeks) to BIO TO.2 hamsters had a significant positive inotropic effect, as indicated by an increase in developed tension up to the levels observed in papillary muscles from normal hamsters. This action is most likely associated with metabolic effects similar to those observed in rats.
Authors:
P Maresca; R Mancinelli; N Corsico; E Arrigoni-Martelli; E Manni
Related Documents :
14305 - Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-mo...
2568455 - Comparative effects of ouabain on isolated papillary muscle from tree shrews, guinea-pi...
22054985 - Influence of age at slaughter, rearing technique and pre-slaughter treatment on some qu...
1486605 - Structure and protein composition of sites of papillary muscle attachment to chordae te...
19058845 - The mechanical properties of individual, electrospun fibrinogen fibers.
1483055 - Severe periodic febrile myalgia in infancy due to carnitine palmitoyltransferase defici...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  287     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-13     Completed Date:  1997-01-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Affiliation:
Dipartimento di Farmacologia, Sigma-Tau S.p.A., Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Analysis of Variance
Animals
Biomechanics
Cardiomyopathy, Dilated / drug therapy*
Cardiotonic Agents / administration & dosage,  pharmacology,  therapeutic use*
Carnitine / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Cricetinae
Disease Models, Animal
Genetic Diseases, Inborn / drug therapy
Male
Mesocricetus
Myocardial Contraction / drug effects*
Papillary Muscles / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 17298-37-2/propionylcarnitine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor ago...
Next Document:  The alpha 1-adrenoceptor agonist, SDZ NVI-085, behaves as a potent, competitive antagonist of 5-hydr...