Document Detail

A positive sentinel lymph node in periocular invasive squamous cell carcinoma: a case series.
MedLine Citation:
PMID:  23034693     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this article was to describe positive sentinel lymph node biopsy (SLNB) findings in patients with periocular invasive squamous cell carcinoma (SCC).
METHODS: This was a retrospective chart review of 5 patients with invasive SCC of the periocular region who underwent SLNB and were found to have regional metastasis.
RESULTS: All patients had large (2.0-4.3 cm) primary tumors with poor differentiation on pathology. In all 5 patients, SLNB was positive in the absence of other signs or evidence of regional or systemic metastasis. While tumor cells may drain to the preauricular or the submandibular basin, the preauricular lymph node was identified as the sentinel lymph node on lymphoscintigraphy in all 5 patients. With a positive sentinel lymph node, the results of SLNB changed the clinical staging and influenced subsequent treatment recommendations for each patient. We identified no complications related to SLNB including facial nerve damage, lymphedema, or allergic reaction to radioactive tracing material.
CONCLUSIONS: In this series of patients with periocular invasive SCC, SLNB was well tolerated and uncovered regional metastasis in patients with no clinical signs of metastasis otherwise. The SLNB findings influenced subsequent oncologic management recommendations. The usefulness of SLNB for poorly differentiated SCC remains uncertain. Further research is necessary to establish the role of SLNB in periocular SCC.
Garrick Chak; Payam V Morgan; Jeffrey M Joseph; Jeremiah P Tao
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  29     ISSN:  1537-2677     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-06-20     Revised Date:  2014-01-08    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / radionuclide imaging,  secondary*,  surgery
Eyelid Neoplasms / pathology*,  radionuclide imaging,  surgery
Lymph Nodes / pathology*,  radiography,  radionuclide imaging
Lymphatic Metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Radiopharmaceuticals / diagnostic use
Retrospective Studies
Sentinel Lymph Node Biopsy
Technetium Tc 99m Sulfur Colloid / diagnostic use
Tomography, X-Ray Computed
Reg. No./Substance:
0/Radiopharmaceuticals; 556Q0P6PB1/Technetium Tc 99m Sulfur Colloid

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