| Positive Outcomes of High Hemoglobin Target in Patients With Chronic Kidney Disease Not on Dialysis: A Randomized Controlled Study. | |
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MedLine Citation:
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PMID: 21974695 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Correcting anemia in patients with chronic kidney disease (CKD) to higher hemoglobin (Hb) levels may be associated with increased risk. No optimal target for Hb has been established. This controlled study examined 321 patients with CKD who were not on dialysis, had a Hb level of <10 g/dL, and a serum creatinine of 2.0 to 6.0 mg/dL. They were randomized into two target Hb groups: 161 to high Hb (11.0-13.0 g/dL) to receive darbepoetin alfa and low Hb to 160 (9.0-11.0 g/dL) to receive recombinant erythropoietin. The study lasted 48 weeks. Of 154 and 153 patients with adverse events, cardiovascular adverse events developed in 42 and 51 patients in the high and low Hb groups, respectively, with no significant difference in the incidence. All quality of life scores improved in the high Hb group and vitality improved significantly more with high Hb (P = 0.025). The left ventricular mass index (LVMI) remained stable in the low Hb group, but there was a significant decrease in LVMI in the high group (P < 0.001). There were no safety concerns with targeting a higher Hb level during the 48 weeks of this study. Patients with a higher Hb target had comparatively better outcomes with respect to quality of life and LVMI. |
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Authors:
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Tadao Akizawa; Fumitake Gejyo; Shinichi Nishi; Yasuhiko Iino; Yuzou Watanabe; Masashi Suzuki; Akira Saito; Takashi Akiba; Hideki Hirakata; Shunichi Fukuhara; Satoshi Morita; Michiaki Hiroe; Yoshiyuki Hada; Makoto Suzuki; Makoto Akaishi; Manabu Iwasaki; Yoshiharu Tsubakihara; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 15 ISSN: 1744-9987 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: - |
Other Details:
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Languages: ENG Pagination: 431-440 Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Therapeutic Apheresis and Dialysis © 2011 International Society for Apheresis. |
Affiliation:
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Showa University School of Medicine Nippon Medical School Hospital Tokyo Women's Medical University Hospital International Medical Center of Japan Sakakibara Memorial Clinic Toho University Ohashi Medical Center Kitasato University Kitasato Institute Hospital Seikei University, Tokyo Niigata University Medical and Dental Hospital Shinrakuen Hospital, Niigata Kobe University Graduate School of Medicine, Kobe Kasugai Municipal Hospital, Kasugai International University of Health and Welfare Atami Hospital, Atami Japanese Red Cross Fukuoka Hospital, Fukuoka Kyoto University Graduate School of Medicine, Kyoto Yokohama City University General Medical Center, Yokohama Osaka General Medical Center, Osaka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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