Document Detail


Positive FP-CIT SPECT (DaTSCAN) in Clinical Alzheimer's Disease - An Unexpected Finding?
MedLine Citation:
PMID:  22545039     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Clinically, Alzheimer's disease (AD) is by far the most common cause of dementia. Criteria for the diagnosis of dementia with Lewy bodies (DLB) are highly specific but not at all sensitive, which is reflected by the higher number of DLB cases detected histopathologically at autopsy. Imaging of dopamine transporter with FP-CIT SPECT is one possibility to increase sensitivity. Pathological confirmation was also included in the revised consensus criteria for the diagnosis of DLB. However, in the absence of parkinsonism, one of the core features, a clinical diagnosis of AD is more likely. The role of FP-CIT SPECT in DLB diagnosis remains to be clarified. Based on our 3 case reports and a review of the literature, the utility of this imaging method in the differential diagnosis of AD and DLB is highlighted.
Authors:
Verena Bittner; Gerhard Ullrich; Markus Thormann; Notger G Müller; Christin Friederichs; Holger Amthauer; Hans-Jochen Heinze; Daniel M Bittner
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Publication Detail:
Type:  Journal Article     Date:  2011-09-21
Journal Detail:
Title:  Dementia and geriatric cognitive disorders extra     Volume:  1     ISSN:  1664-5464     ISO Abbreviation:  Dement Geriatr Cogn Dis Extra     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101564825     Medline TA:  Dement Geriatr Cogn Dis Extra     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  283-91     Citation Subset:  -    
Affiliation:
Departments of Neurology, Magdeburg, University of Magdeburg, Magdeburg, Germany.
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