Document Detail


Positioning of chemosensory clusters in E. coli and its relation to cell division.
MedLine Citation:
PMID:  17332753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chemotaxis receptors and associated signalling proteins in Escherichia coli form clusters that consist of thousands of molecules and are the largest native protein complexes described to date in bacteria. Clusters are located at the cell poles and laterally along the cell body, and play an important role in signal transduction. Much work has been done to study the structure and function of receptor clusters, but the significance of their positioning and the underlying mechanisms are not understood. Here, we used fluorescence imaging to study cluster distribution and follow cluster dynamics during cell growth. Our data show that lateral clusters localise to specific periodic positions along the cell body, which mark future division sites and are involved in the localisation of the replication machinery. The chemoreceptor cluster positioning is thus intricately related to the overall structure and division of an E. coli cell.
Authors:
Sebastian Thiem; David Kentner; Victor Sourjik
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-01
Journal Detail:
Title:  The EMBO journal     Volume:  26     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-07-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1615-23     Citation Subset:  IM    
Affiliation:
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Cell Division / physiology*
Chemotaxis / physiology*
Escherichia coli / cytology,  metabolism,  physiology*
Image Processing, Computer-Assisted
Microscopy, Fluorescence
Multiprotein Complexes / metabolism,  physiology*
Receptors, Cell Surface / metabolism,  physiology*
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/Multiprotein Complexes; 0/Receptors, Cell Surface
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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