Document Detail

Positioning of chemosensory clusters in E. coli and its relation to cell division.
MedLine Citation:
PMID:  17332753     Owner:  NLM     Status:  MEDLINE    
Chemotaxis receptors and associated signalling proteins in Escherichia coli form clusters that consist of thousands of molecules and are the largest native protein complexes described to date in bacteria. Clusters are located at the cell poles and laterally along the cell body, and play an important role in signal transduction. Much work has been done to study the structure and function of receptor clusters, but the significance of their positioning and the underlying mechanisms are not understood. Here, we used fluorescence imaging to study cluster distribution and follow cluster dynamics during cell growth. Our data show that lateral clusters localise to specific periodic positions along the cell body, which mark future division sites and are involved in the localisation of the replication machinery. The chemoreceptor cluster positioning is thus intricately related to the overall structure and division of an E. coli cell.
Sebastian Thiem; David Kentner; Victor Sourjik
Related Documents :
5327373 - Ultrastructure of escherichia coli cells infected with bacteriophage r17.
5323293 - Properties of rod cells reversed from penicillin spheroplasts in escherichia coli.
6197443 - Sequential requirements for cell cycle progression of resting human b cells after activ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-01
Journal Detail:
Title:  The EMBO journal     Volume:  26     ISSN:  0261-4189     ISO Abbreviation:  EMBO J.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-07-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1615-23     Citation Subset:  IM    
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Division / physiology*
Chemotaxis / physiology*
Escherichia coli / cytology,  metabolism,  physiology*
Image Processing, Computer-Assisted
Microscopy, Fluorescence
Multiprotein Complexes / metabolism,  physiology*
Receptors, Cell Surface / metabolism,  physiology*
Signal Transduction / physiology*
Reg. No./Substance:
0/Multiprotein Complexes; 0/Receptors, Cell Surface

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A sigma-core interaction of the RNA polymerase holoenzyme that enhances promoter escape.
Next Document:  The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axo...