| Positional ocular flutter and thickened optic nerves as sentinel signs of Krabbe disease. | |
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MedLine Citation:
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PMID: 22153408 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 5-month-old boy developed a large-amplitude, horizontal pendular flutterlike oscillation of the eyes, when placed in the supine position. Magnetic resonance imaging (MRI) 1 month earlier had shown isolated thickening of the optic nerves and chiasm without other central nervous system signal abnormalities. Repeat MRI at 5½ months of age showed a constellation of central nervous system signal abnormalities suggestive of Krabbe disease. The diagnosis was confirmed with serum enzymatic and genetic testing. This case demonstrates that positional ocular flutter can be a presenting sign of Krabbe disease and reinforces the observation that isolated thickening of the anterior visual pathways can antedate other central nervous system abnormalities on MRI. |
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Authors:
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Michael C Brodsky; Jeffrey S Hunter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus Volume: 15 ISSN: 1528-3933 ISO Abbreviation: J AAPOS Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9710011 Medline TA: J AAPOS Country: United States |
Other Details:
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Languages: eng Pagination: 595-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Mosby, Inc. |
Affiliation:
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Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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