Document Detail

Positional information and patterning revisited.
MedLine Citation:
PMID:  21044633     Owner:  NLM     Status:  In-Data-Review    
The concept of positional information proposes that cells acquire positional values as in a coordinate system, which they interpret by developing in particular ways to give rise to spatial patterns. Some of the best evidence for positional information comes from regeneration experiments, and the patterning of the leg and antenna in Drosophila and the vertebrate limb. Central problems are how positional information is set up, how it is recorded, and then how it is interpreted by the cells. A number of models have been proposed for the setting up of positional gradients, and most are based on diffusion of a morphogen and its interactions with extracellular molecules. It is argued that diffusion may not be reliable mechanism. There are also mechanisms based on timing. There is no good evidence for the quantitative aspects of any of the gradients and details how they are set up. The way in which a signalling gradient regulates differential gene expression in a concentration-dependent manner also raises several mechanistic issues.
Lewis Wolpert
Related Documents :
21952973 - First report of elasmus polistis burks (hymenoptera: eulophidae) recovered from poliste...
6223053 - Erythroderma: a follow-up of fifty cases.
23806763 - Renal carcinoma relapse presenting as a peripheral nerve sheath tumor: a case report an...
Publication Detail:
Type:  Journal Article     Date:  2010-10-31
Journal Detail:
Title:  Journal of theoretical biology     Volume:  269     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  359-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Cell and Developmental Biology, University College, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Real-time, high-throughput measurements of peptide-MHC-I dissociation using a scintillation proximit...
Next Document:  When two trees go to war.