Document Detail


Positional information and pattern formation.
MedLine Citation:
PMID:  6117904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spatial patterns of cellular differentiation may arise from cells first being assigned a position, as in a coordinate system, and then interpreting the positional value that they have acquired. This interpretation will depend on their genetic constitution and developmental history. Different patterns may thus arise from similar positional fields. The specification of positional value may involve a positional signal, such as the concentration of a diffusible morphogen, but can also depend on how long the cells remain in a particular region, such as a progress zone. Positional values may also be acquired by direct transfer from one cell layer to another, as in directed embryonic induction. Positional value, unlike a positional signal, involves long-term memory, and can be regarded as a type of cell determination. Cells of the same differentiation class may have different positional values and may thus be non-equivalent. Evidence is presented for a signal providing positional information along the antero-posterior axis during chick limb development. This signal has properties similar to those of a diffusible morphogen.
Authors:
L Wolpert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  295     ISSN:  0962-8436     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  441-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Aggregation*
Cell Movement
Chick Embryo
Embryonic Induction
Extremities / embryology
Morphogenesis*

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