Document Detail

Positional changes of the frontoparietal ossification centers in perinatal craniosynostotic rabbits.
MedLine Citation:
PMID:  10416149     Owner:  NLM     Status:  MEDLINE    
It has been suggested that craniosynostosis is caused by abnormally located ossification centers (i.e., bony tubers) in the developing skull prior to suture formation [Mathijssen et al., 1996, 1997]. The present study was designed to test this hypothesis in a rabbit model of human familial, nonsyndromic coronal suture (CS) synostosis. Calvariae were taken from 99 New Zealand White rabbit perinates (55 normal controls, 15 with delayed-onset CS synostosis, and 29 with bilateral or unilateral CS synostosis), ranging in age from 23 to 34 days postconception (synostosis occurs at approximately 23 days in this model). Frontoparietal, interfrontal, and interparietal ossification center distances were obtained using a Wild microscope with camera lucida attachment and a 2-D computer digitization technique. Linear regression analysis was used to compare age-related changes in the perinatal ossification centers among groups. Results revealed that frontoparietal ossification center regression line slopes had similar start points (24-day intercepts) with significantly (P < 0.05) diverging slopes over time. Normal and delayed-onset ossification center distance increased more rapidly than in synostosed perinates. No significant (P > 0.05) differences were noted in regression line slopes among groups for interparietal or interfrontal ossification center distances. Results demonstrated that, in synostosed perinates, frontoparietal ossification center location was similar to normals around the time of synostosis and became displaced later. These findings suggest that ossification center (i.e., bony tuber) displacement seen in infants with craniosynostosis is probably a secondary and compensatory, postsynostotic change and not a primary causal factor of synostosis in this rabbit model.
J J Dechant; M P Mooney; G M Cooper; T D Smith; A M Burrows; H W Losken; I M Mathijssen; M I Siegel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of craniofacial genetics and developmental biology     Volume:  19     ISSN:  0270-4145     ISO Abbreviation:  J. Craniofac. Genet. Dev. Biol.     Publication Date:    1999 Apr-Jun
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109845     Medline TA:  J Craniofac Genet Dev Biol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  64-74     Citation Subset:  IM    
Department of Anthropology, School of Nursing, University of Pittsburgh, PA 15261, USA.
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MeSH Terms
Bone Development
Cranial Sutures / abnormalities,  embryology,  pathology
Craniosynostoses / diagnosis*,  embryology*
Frontal Bone / abnormalities*,  anatomy & histology,  embryology*,  pathology
Linear Models
Parietal Bone / abnormalities*,  anatomy & histology,  embryology*,  pathology
Reference Values
Tomography, X-Ray Computed
Grant Support

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