Document Detail

Position statement: ipecac syrup. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.
MedLine Citation:
PMID:  9482425     Owner:  NLM     Status:  MEDLINE    
In preparing this Position Statement, all relevant scientific literature was identified and reviewed critically by acknowledged experts using agreed criteria. Well-conducted clinical and experimental studies were given precedence over anecdotal case reports and abstracts were not usually considered. A draft Position Statement was then produced and subjected to detailed peer review by an international group of clinical toxicologists chosen by the American Academy of Clinical Toxicology and the European Association of Poisons Centres and Clinical Toxicologists. The Position Statement went through multiple drafts before being approved by the boards of the two societies and being endorsed by other societies. The Position Statement includes a summary statement for ease of use and is supported by detailed documentation which describes the scientific evidence on which the Statement is based. Syrup of ipecac should not be administered routinely in the management of poisoned patients. In experimental studies the amount of marker removed by ipecac was highly variable and diminished with time. There is no evidence from clinical studies that ipecac improves the outcome of poisoned patients and its routine administration in the emergency department should be abandoned. There are insufficient data to support or exclude ipecac administration soon after poison ingestion. Ipecac may delay the administration or reduce the effectiveness of activated charcoal, oral antidotes, and whole bowel irrigation. Ipecac should not be administered to a patient who has a decreased level or impending loss of consciousness or who has ingested a corrosive substance or hydrocarbon with high aspiration potential.
E P Krenzelok; M McGuigan; P Lheur
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Publication Detail:
Type:  Case Reports; Guideline; Journal Article; Practice Guideline; Review    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  35     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1997  
Date Detail:
Created Date:  1998-03-11     Completed Date:  1998-03-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-709     Citation Subset:  AIM; IM    
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MeSH Terms
Acetaminophen / poisoning
Administration, Oral
Antidotes / therapeutic use
Charcoal / therapeutic use
Child, Preschool
Clinical Trials as Topic
Emetics / contraindications,  therapeutic use*
Ferrous Compounds / poisoning
Intestinal Absorption
Ipecac / adverse effects,  contraindications,  therapeutic use*
Poisoning / drug therapy*
Randomized Controlled Trials as Topic
Vomiting / chemically induced
Reg. No./Substance:
0/Antidotes; 0/Emetics; 0/Ferrous Compounds; 103-90-2/Acetaminophen; 16291-96-6/Charcoal; 7720-78-7/ferrous sulfate; 8012-96-2/Ipecac
Comment In:
J Toxicol Clin Toxicol. 2000;38(7):689-90   [PMID:  11192453 ]

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