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Position of the conus medullaris in fetuses with skeletal dysplasia.
MedLine Citation:
PMID:  23161263     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To examine whether reduced conus distance (CD) measurement may be a marker for impaired growth of the fetal trunk in fetuses with certain types of skeletal dysplasia. METHODS: Two hundred fifty-four normal cases and 24 pregnancies with skeletal dysplasia were included. The fetuses with skeletal dysplasia were subdivided into two groups based on the specific diagnosis: skeletal dysplasias with a short trunk and skeletal dysplasias with a normal size trunk. Linear regression analysis was used to examine the relationship of the CD measurement with the biparietal diameter. CD measurements in the two groups of fetuses with skeletal dysplasia were compared using z-scores. RESULTS: In fetuses with skeletal dysplasia and shortened trunk, the CD measurement was significantly smaller than in the normal population (mean z-score -3.7, p < 0.0001). CD measurements in fetuses with skeletal dysplasia but a normal trunk size were similar to the normal population (mean z-score -0.1, p = 0.997). CONCLUSIONS: Short CD is associated with certain types of skeletal dysplasia. As such, measuring the CD may be helpful in diagnosing these conditions. © 2012 John Wiley & Sons, Ltd.
Authors:
Markus Hoopmann; Jiri Sonek; Thomas Schramm; Wolfgang Zubke; Andreas Dufke; Karl Oliver Kagan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany.
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