Document Detail


Posaconazole: the case for therapeutic drug monitoring.
MedLine Citation:
PMID:  22215487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invasive fungal infections are associated with high morbidity and mortality. Antifungal therapeutic options remain relatively limited; therefore, optimization of present regimens is essential. Posaconazole is licensed for prevention of invasive fungal infections and oropharyngeal candidiasis and salvage therapy for invasive aspergillosis. Recent data suggest that therapeutic drug monitoring may be an important tool for patient management. Clinical and laboratory animal data suggest that posaconazole demonstrates clinically relevant exposure-response relationships. Higher systemic drug exposure is associated with improved clinical outcomes. Potentially subtherapeutic concentrations are frequently encountered in critically ill patients. Therapeutic drug monitoring provides a way to optimize the use of posaconazole, and this review summarizes the indications and process by which this can be achieved.
Authors:
Susan J Howard; Timothy W Felton; Alicia Gomez-Lopez; William W Hope
Related Documents :
8599727 - Drug trials in neuropathy.
1477247 - Evaluation of new anti-infective drugs for surgical prophylaxis. infectious diseases so...
16987157 - Efns guidelines on management of restless legs syndrome and periodic limb movement diso...
21568917 - Aspartic protease inhibitors as potential anti-candida albicans drugs: impacts on funga...
19596887 - In vitro activities of trioxaquines against schistosoma mansoni.
9572317 - Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  34     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-05-15     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / blood*,  pharmacokinetics*
Drug Monitoring*
Humans
Mycoses / prevention & control
Triazoles / blood*,  pharmacokinetics*
Grant Support
ID/Acronym/Agency:
G1000417//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Triazoles; 6TK1G07BHZ/posaconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a ca...
Next Document:  The Role of Therapeutic Drug Monitoring of Imatinib in Patients with Chronic Myeloid Leukemia and Me...