Document Detail


Posaconazole: the case for therapeutic drug monitoring.
MedLine Citation:
PMID:  22215487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invasive fungal infections are associated with high morbidity and mortality. Antifungal therapeutic options remain relatively limited; therefore, optimization of present regimens is essential. Posaconazole is licensed for prevention of invasive fungal infections and oropharyngeal candidiasis and salvage therapy for invasive aspergillosis. Recent data suggest that therapeutic drug monitoring may be an important tool for patient management. Clinical and laboratory animal data suggest that posaconazole demonstrates clinically relevant exposure-response relationships. Higher systemic drug exposure is associated with improved clinical outcomes. Potentially subtherapeutic concentrations are frequently encountered in critically ill patients. Therapeutic drug monitoring provides a way to optimize the use of posaconazole, and this review summarizes the indications and process by which this can be achieved.
Authors:
Susan J Howard; Timothy W Felton; Alicia Gomez-Lopez; William W Hope
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  34     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-05-15     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / blood*,  pharmacokinetics*
Drug Monitoring*
Humans
Mycoses / prevention & control
Triazoles / blood*,  pharmacokinetics*
Grant Support
ID/Acronym/Agency:
G1000417//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Triazoles; 6TK1G07BHZ/posaconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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