| Portosystemic collaterals are not prerequisites for the development of hepatic encephalopathy in cirrhotic rats. | |
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MedLine Citation:
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PMID: 22240529 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Liver functions and portosystemic collaterals influence the development and severity of hepatic encephalopathy (HE) in cirrhosis. However, it has not been examined which factor has a greater influence or if shunts can be used to determine the presence and severity of HE. The expression of tumor necrosis factor-α (TNF-α) is increased in cirrhosis, and its role in HE deserves further evaluation. METHODS: Portal hypertension was induced by portal vein ligation (PVL; a model of high-degree portosystemic shunting without significant liver damage) and liver cirrhosis was induced by bile duct ligation (BDL; a model of low-degree shunting with liver cirrhosis) in male Spraque-Dawley rats. Sham-operated rats were used as controls. Motor activity counts, hemodynamic parameters, plasma levels, liver biochemistry parameters, TNF-α, and a flow-pressure curve study of portosystemic collaterals (where a higher slope indicates fewer portosystemic collaterals) were performed on Day 7 after PVL and Week 5 after BDL. RESULTS: Portal pressure was significantly higher in the PVL and BDL groups than in controls. The liver biochemistry parameters, TNF-α, and motor activities were not significantly different between the PVL and PVL-control groups. In the BDL group, TNF-α, AST, and total bilirubin levels were significantly higher and the motor activity counts were lower than in the BDL-control group. Moreover, in the BDL rats, TNF-α (p=0.037, R=-0.490), AST (p=0.007, R=-0.595) and total bilirubin (P=0.001, R=-0.692) levels, but not the slopes of the flow-pressure curves, were significantly and negatively correlated with the motor activity counts. CONCLUSION: The presence of a high degree of portosystemic shunting without significant liver damage may not be adequate for the development of HE. |
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Authors:
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I-Fang Hsin; Sun-Sang Wang; Hui-Chun Huang; Fa-Yauh Lee; Cho-Yu Chan; Ching-Chih Chang; Chia-Yang Hsu; Han-Chieh Lin; Shou-Dong Lee |
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Publication Detail:
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Type: Journal Article Date: 2011-11-23 |
Journal Detail:
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Title: Journal of the Chinese Medical Association : JCMA Volume: 75 ISSN: 1728-7731 ISO Abbreviation: J Chin Med Assoc Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101174817 Medline TA: J Chin Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 3-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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