Document Detail

Portopulmonary hypertension in children. A study in pediatric autopsies.
MedLine Citation:
PMID:  20082881     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: The relative frequency and risk factors of portopulmonary hypertension in children have not been defined with precision. The few published reports refer to isolated cases or small series from selected populations. The development of pulmonary hypertension in patients with portal hypertension is seldom suspected or documented during life. The examination of autopsy material can identify these cases because pulmonary hypertension produces characteristic histological changes in the pulmonary vasculature. METHODS: Autopsy cases with evidence of portal hypertension were retrieved. Slides of pulmonary tissue from these cases were examined in search of histopathological changes of hypertensive arteriopathy RESULTS: Seventy six cases of portal hypertension were identified among 7060 autopsies collected between January 1971 and January 2008 (1.07%). Four cases with histopathological evidence of pulmonary hypertension were identified. This represents 5.2% of all cases with portal hypertension. These four patients were females in late childhood or adolescence with idiopathic portal hypertension. Pulmonary hypertension was not diagnosed during their lifetime. CONCLUSIONS: Idiopathic portal hypertension in adolescent girls should be considered a risk factor for the development of portopulmonary hypertension, very likely as a consequence of the functional preservation of hepatic tissue that allows a prolonged survival. An oriented search for early signs of pulmonary hypertension in these patients would appear advisable in order to install timely treatment.
Cecilia Ridaura-Sanz; Carmen Mej?a-Hern?ndez; Eduardo L?pez-Corella
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of medical research     Volume:  40     ISSN:  1873-5487     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-9     Citation Subset:  IM    
Copyright Information:
2009 IMSS. Published by Elsevier Inc.
Department of Pathology, National Institute of Pediatrics, Mexico City, Mexico.
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MeSH Terms
Child, Preschool
Hypertension, Portal / diagnosis*,  epidemiology*,  etiology,  pathology
Hypertension, Pulmonary / diagnosis*,  epidemiology*,  etiology,  pathology
Lung / pathology
Pulmonary Circulation
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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