Document Detail

Portal venous pressure and portasystemic shunting in experimental portal hypertension.
MedLine Citation:
PMID:  2750909     Owner:  NLM     Status:  MEDLINE    
The relationship between portal venous pressure and the degree of portasystemic shunting was studied in portal vein-ligated and cirrhotic rats anesthetized with halothane. One day after partial portal vein ligation there was a strong positive correlation (r = 0.80, n = 7) between portal pressure and shunting of mesenteric venous blood as measured by injection of radioactive microspheres. The relationship subsequently underwent rapid change but stabilized by 14 days postligation, when higher levels of shunting were again associated with higher portal pressures up to a limit of approximately 70% shunting, above which pressures did not increase further. This relationship was well described by a quadratic function (r = 0.75, n = 17). In cirrhotic rats there was no relationship between portal pressure and shunting (r = -0.01, n = 10). The results suggest that in the prehepatic model there is little inherent variability in capacity to develop shunts, which open to a degree directly related to portal pressure, but that this relationship may be altered in cirrhotic portal hypertension.
J G Geraghty; W J Angerson; D C Carter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-11     Completed Date:  1989-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G52-7     Citation Subset:  IM    
University Department of Surgery, Royal Infirmary, Glasgow, United Kingdom.
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MeSH Terms
Hypertension, Portal / physiopathology*
Liver Cirrhosis / physiopathology
Mesenteric Veins / physiopathology
Portal Vein / physiopathology*
Rats, Inbred Strains
Venous Pressure*

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