Document Detail

Portal venous flow during CO(2) pneumoperitoneum in the rat.
MedLine Citation:
PMID:  10449849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: CO(2) gas insufflation is routinely used to extend the abdominal wall. The resulting pneumoperitoneum has a number of local and systemic effects on the organism. Portal blood flow, which plays an important role in hepatic function and cell-conveyed immune response, is one of the affected parameters. METHODS: An established animal model (rat) of laparoscopic surgery was modified by implanting a perivascular flow probe. Hemodynamics in the portal vein were then measured during increasing intraabdominal pressure generated by carbon dioxide insufflation. RESULTS: Using this technique, an adequate flowmetry of the portal vein was achieved in all animals. The creation of a CO(2) pneumoperitoneum with increasing intraabdominal pressure led to a linear decrease in portal venous flow. CONCLUSIONS: Elevated intraabdominal pressure caused by carbon dioxide insufflation may compromise hepatic function and cell-conveyed immune response during laparoscopic surgery.
C N Gutt; T C Schmandra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical endoscopy     Volume:  13     ISSN:  0930-2794     ISO Abbreviation:  Surg Endosc     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  902-5     Citation Subset:  IM    
Department of General and Vascular Surgery, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
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MeSH Terms
Abdomen / physiology
Blood Flow Velocity*
Carbon Dioxide*
Pneumoperitoneum, Artificial*
Portal Vein / physiology*
Rats, Sprague-Dawley
Reg. No./Substance:
124-38-9/Carbon Dioxide

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