Document Detail


Portal vein thrombosis: what is the role of genetics?
MedLine Citation:
PMID:  15947546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aetiology of portal vein thrombosis (PVT) in adults is complex. Risk factors include local precipitating factors and acquired and inherited factors, an area in which there has been much recent progress. Although PVT in the absence of cirrhosis may be regarded as a somewhat different disorder to PVT in the presence of cirrhosis, in both cases most studies support a role of the prothrombin G20210A mutation. Some differences in risk factors observed between different studies may relate partly to referral patterns or study design, although individual patients may develop PVT as a result of differing combinations of risk factors. The demonstration of an inherited thrombophilic mutation in a subset of PVT may ultimately inform clinical management regarding the use and duration of anticoagulation therapy, although there is a need for evidence from randomized-controlled clinical trial data.
Authors:
Ann P Walker
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  17     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-10     Completed Date:  2006-01-09     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  705-7     Citation Subset:  IM    
Affiliation:
Centre for Hepatology, Division of Medicine, Royal Free and University College Medical School, University College London, UK. ann.walker@medsch.ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithrombins / genetics
Blood Coagulation Factor Inhibitors / genetics
Factor V / genetics
Humans
Liver Cirrhosis / complications,  genetics
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Mutation
Portal Vein*
Prothrombin / genetics
Risk Factors
Venous Thrombosis / etiology,  genetics*
Chemical
Reg. No./Substance:
0/Antithrombins; 0/Blood Coagulation Factor Inhibitors; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)
Comments/Corrections
Comment On:
Eur J Gastroenterol Hepatol. 2005 Jul;17(7):745-51   [PMID:  15947552 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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