| Portal vein thrombosis in the neonate: risk factors, course, and outcome. | |
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MedLine Citation:
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PMID: 16769378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the risk factors, clinical features, and outcome of infants diagnosed with portal vein thrombosis (PVT). STUDY DESIGN: A retrospective chart review was conducted of all consecutive infants admitted to the Hospital for Sick Children, Toronto, between January 1999 and December 2003 diagnosed with PVT. RESULTS: PVT was diagnosed in 133 infants, all but 5 of whom were neonates, with a median age at time of diagnosis of 7 days. An umbilical venous catheter (UVC) was inserted in 73% of the infants and was in an appropriate position in 46% of them. Poor outcome, defined as portal hypertension or lobar atrophy, was diagnosed in 27% of the infants and was significantly more common in those with an initial diagnosis of grade 3 PVT and in those with a low or intrahepatically placed UVC. Anticoagulation treatment did not appear to have a significant effect on outcome. CONCLUSIONS: PVT occurs early in life; major risk factors in addition to the neonatal period are placement of UVC and severe neonatal sickness. Poor outcome is associated with an improperly placed UVC and with grade 3 thrombus. |
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Authors:
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Iris Morag; Monica Epelman; Alan Daneman; Rahim Moineddin; Boriana Parvez; Tal Shechter; Jonathan Hellmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 148 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-13 Completed Date: 2006-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 735-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Neonatology and Diagnostic Imaging, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. dr._iris@walla.co.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catheterization
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adverse effects* Disease Progression Female Humans Infant, Newborn Male Portal Vein* Retrospective Studies Risk Factors Treatment Outcome Umbilical Veins* Venous Thrombosis / epidemiology, etiology* |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2006 Jun;148(6):715-6
[PMID:
16769372
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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