Document Detail

Portal vein thrombosis in the neonate: risk factors, course, and outcome.
MedLine Citation:
PMID:  16769378     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the risk factors, clinical features, and outcome of infants diagnosed with portal vein thrombosis (PVT). STUDY DESIGN: A retrospective chart review was conducted of all consecutive infants admitted to the Hospital for Sick Children, Toronto, between January 1999 and December 2003 diagnosed with PVT. RESULTS: PVT was diagnosed in 133 infants, all but 5 of whom were neonates, with a median age at time of diagnosis of 7 days. An umbilical venous catheter (UVC) was inserted in 73% of the infants and was in an appropriate position in 46% of them. Poor outcome, defined as portal hypertension or lobar atrophy, was diagnosed in 27% of the infants and was significantly more common in those with an initial diagnosis of grade 3 PVT and in those with a low or intrahepatically placed UVC. Anticoagulation treatment did not appear to have a significant effect on outcome. CONCLUSIONS: PVT occurs early in life; major risk factors in addition to the neonatal period are placement of UVC and severe neonatal sickness. Poor outcome is associated with an improperly placed UVC and with grade 3 thrombus.
Iris Morag; Monica Epelman; Alan Daneman; Rahim Moineddin; Boriana Parvez; Tal Shechter; Jonathan Hellmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  148     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  735-9     Citation Subset:  AIM; IM    
Division of Neonatology and Diagnostic Imaging, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Catheterization / adverse effects*
Disease Progression
Infant, Newborn
Portal Vein*
Retrospective Studies
Risk Factors
Treatment Outcome
Umbilical Veins*
Venous Thrombosis / epidemiology,  etiology*
Comment In:
J Pediatr. 2006 Jun;148(6):715-6   [PMID:  16769372 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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