| Portal vein thrombosis in liver cirrhosis. | |
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MedLine Citation:
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PMID: 18274708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Portal vein thrombosis (PVT) is observed in 10-20% of patients with liver cirrhosis, which is responsible for 20% of all PVT cases. The main pathogenic factor of PVT in cirrhosis is the obstacle to portal flow, but acquired and inherited clotting abnormalities may play a role. The formation of collateral veins allows many patients to remain asymptomatic and prevents the onset of clinical complications also in patients with totally occlusive PVT. Gastrointestinal bleeding, thrombosis of superior mesenteric vein and refractory ascites are typical manifestations of PVT. Instrumental diagnosis can be obtained by colour-doppler ultrasonography. Future studies should verify whether asymptomatic PVT worsens liver failure, or if its life-threatening complications reduce survival in patients with cirrhosis. Moreover, randomized controlled trials should clarify the potential effectiveness of anticoagulant therapy in the treatment of PVT. |
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Authors:
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Filippo Luca Fimognari; Francesco Violi |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-02-15 |
Journal Detail:
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Title: Internal and emergency medicine Volume: 3 ISSN: 1828-0447 ISO Abbreviation: - Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-12 Completed Date: 2008-12-16 Revised Date: 2009-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101263418 Medline TA: Intern Emerg Med Country: Italy |
Other Details:
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Languages: eng Pagination: 213-8 Citation Subset: IM |
Affiliation:
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Division of Internal Medicine, ASL Roma G, Leopoldo Parodi-Delfino Hospital, Colleferro, Rome, Italy. filippo.fimognari@virgilio.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Liver Cirrhosis / complications* Portal Vein* Venous Thrombosis / diagnosis, etiology*, physiopathology, therapy |
| Comments/Corrections | |
Comment In:
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Intern Emerg Med. 2009 Apr;4(2):161-2; author reply 163-4
[PMID:
19130177
]
Intern Emerg Med. 2008 Sep;3(3):195-6 [PMID: 18648753 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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