Document Detail

Portal vein thrombosis in liver cirrhosis.
MedLine Citation:
PMID:  18274708     Owner:  NLM     Status:  MEDLINE    
Portal vein thrombosis (PVT) is observed in 10-20% of patients with liver cirrhosis, which is responsible for 20% of all PVT cases. The main pathogenic factor of PVT in cirrhosis is the obstacle to portal flow, but acquired and inherited clotting abnormalities may play a role. The formation of collateral veins allows many patients to remain asymptomatic and prevents the onset of clinical complications also in patients with totally occlusive PVT. Gastrointestinal bleeding, thrombosis of superior mesenteric vein and refractory ascites are typical manifestations of PVT. Instrumental diagnosis can be obtained by colour-doppler ultrasonography. Future studies should verify whether asymptomatic PVT worsens liver failure, or if its life-threatening complications reduce survival in patients with cirrhosis. Moreover, randomized controlled trials should clarify the potential effectiveness of anticoagulant therapy in the treatment of PVT.
Filippo Luca Fimognari; Francesco Violi
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-02-15
Journal Detail:
Title:  Internal and emergency medicine     Volume:  3     ISSN:  1828-0447     ISO Abbreviation:  -     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-12-16     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  101263418     Medline TA:  Intern Emerg Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  213-8     Citation Subset:  IM    
Division of Internal Medicine, ASL Roma G, Leopoldo Parodi-Delfino Hospital, Colleferro, Rome, Italy.
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MeSH Terms
Liver Cirrhosis / complications*
Portal Vein*
Venous Thrombosis / diagnosis,  etiology*,  physiopathology,  therapy
Comment In:
Intern Emerg Med. 2009 Apr;4(2):161-2; author reply 163-4   [PMID:  19130177 ]
Intern Emerg Med. 2008 Sep;3(3):195-6   [PMID:  18648753 ]

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