| Portal vein hemodynamics in patients with non-alcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 18509239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paralleling the rise in the incidence of obesity and diabetes worldwide, nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as one of the major causes of chronic liver disease. Doppler sonography is used as a diagnostic method in the non-invasive assessment of the hemodynamics of hepatic vascular flow in liver diseases. We investigated the effects of fatty infiltration in the liver on the Doppler flow hemodynamics of the portal vein. Doppler sonography of the liver and portal vein was performed in 60 subjects with NAFLD and 20 healthy volunteers (control). The patients were grouped into mild (grade 1), moderate (grade 2), and severe (grade 3) according to sonographic appearance of hepatosteatosis (n = 20 for each group). The vein pulsatility index (VPI), mean flow velocity (MFV), peak maximum velocity (V(max)), and peak minimum velocity (V(min)) of the portal vein were significantly lower in patients with NAFLD than those of the controls (p < 0.001). The VPI was 0.20 in the patients and 0.31 in the control. The MFV was 12.3 cm/sec in the patients and 16.5 cm/sec in the control group. The portal vein flow was found to be decreased as the grade of fatty infiltration increased for VPI (r = -0.946, p < 0.001), MFV (r = -0.951, p < 0.001). The alteration in Doppler waveform pattern of portal vein with fatty liver population suggests reduced vascular compliance in the liver. |
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Authors:
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Besir Erdogmus; Ali Tamer; Ramazan Buyukkaya; Burhan Yazici; Ayla Buyukkaya; Esin Korkut; Aytekin Alcelik; Ugur Korkmaz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 215 ISSN: 1349-3329 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-29 Completed Date: 2008-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: Japan |
Other Details:
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Languages: eng Pagination: 89-93 Citation Subset: IM |
Affiliation:
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Department of Radiology, Duzce University, Medical School, Duzce, Turkey. besirerdogmus@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Flow Velocity / physiology Fatty Liver / physiopathology*, ultrasonography Female Hemodynamics / physiology* Humans Male Middle Aged Portal Vein / physiopathology*, ultrasonography Ultrasonography, Doppler / statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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