Document Detail


Portal levels of latent transforming growth factor-β are related to liver function in patients with liver cirrhosis.
MedLine Citation:
PMID:  21228704     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Transforming growth factor-β1 (TGFβ1) is a short-lived immune suppressive and profibrotic protein. Itslatent precursor is relatively stable and may even protect from fibrosis. Latent TGFβ1 is synthesized by various tissues including the liver and portal, hepatic, andsystemic concentrations of latent TGFβ1 were determined in patients with liver cirrhosis and patients withnormal liver function to find out whether circulating levels are affected by liver disease. METHODS: Latent TGFβ1 was measured in portal venous serum (PVS), hepatic venous serum (HVS), and systemic venous serum (SVS) of 26 patients with liver cirrhosis and nine patients with normal liver function. RESULTS: Latent TGFβ1 was similarly abundant in HVS, PVS,andSVS of patients with liver cirrhosis and controls. There was a strong positive correlation of HVS, PVS, and SVS TGFβ1 to each other. PVS levels of latent TGFβ1 were significantly lower in patients with CHILD-PUGH stage C compared with CHILD-PUGH stage A, SVS levels were modestly and HVS levels tended to be reduced. PVS and SVS TGFβ1 concentrations were also lower in patients witha higher model for end-stage liver disease score. OnlyPVS concentrations were reduced in patients with massive ascites compared with the patients without ascites. Creatinine clearance as a marker of renal functionand parameters of coagulation did not correlate with this cytokine indicating that latent TGFβ1 levels are notlinkedto kidney function and coagulation. Interleukin-6, which is elevated in patients with liver cirrhosis negativelycorrelated with latent TGFβ1 in PVS and SVS. CONCLUSION: In patients with liver cirrhosis splanchnic organ-derived latent TGFβ1 is negatively associated with the liver function.
Authors:
Josef Wanninger; Reiner Wiest; Sabrina Bauer; Markus Neumeier; Kristina Eisinger; Stefan Farkas; Marcus N Scherer; Andreas Schäffler; Christa Buechler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-11
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  -     ISSN:  1473-5687     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartments of Internal Medicine I bSurgery, Regensburg University Hospital, Regensburg, Germany.
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